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NF-kappa B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Health and Society. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery VHN.
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2012 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 27, no 4, 447-452 p.Article in journal (Refereed) Published
Abstract [en]

The NF-kappa B transcription factor protein family has diverse cellular and biological functions, and posttranslational modification is important to regulate these functions. An important site of phosphorylation of NF-kappa B p65 subunit is at serine-536 (phospho-Ser536-p65), and this phosphorylation is involved in regulation of transcriptional activity, nuclear localization, and protein stability. less thanbrgreater than less thanbrgreater thanIn this study, we investigated expression of phospho-Ser536-p65 in colorectal cancers and its relationships with clinicopathological factors. The expression of phospho-Ser536-p65 was examined by immunohistochemistry in 203 primary colorectal cancers, 156 normal mucosa specimens, and 18 metastases in the lymph nodes. less thanbrgreater than less thanbrgreater thanThe expression of phospho-Ser536-p65 increased from normal mucosa to primary tumor (p andlt; 0.0001). Further, the increased expression of phospho-Ser536-p65 in the cytoplasm of the primary tumors correlated with worse survival of the patients independently of gender, age, tumor location, stage, and differentiation (p = 0.04; hazard ratio, 1.89; 95% CI 1.03-3.47). less thanbrgreater than less thanbrgreater thanThe NF-kappa B p65 subunit phosphorylated at serine-536 is an independent prognostic factor in colorectal cancer patients.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2012. Vol. 27, no 4, 447-452 p.
Keyword [en]
NF-kappa B, Survival, Colorectal cancer, Immunohistochemistry
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76610DOI: 10.1007/s00384-011-1356-8ISI: 000301777100004OAI: oai:DiVA.org:liu-76610DiVA: diva2:515454
Note
Funding Agencies|Swedish Cancer Foundation||Swedish Research Council||Health Research Council in the Southeast of Sweden||Available from: 2012-04-13 Created: 2012-04-13 Last updated: 2017-12-07

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