Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
Show others and affiliations
2011 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, Vol. 2011, no 212810Article in journal (Refereed) Published
Abstract [en]

Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome. The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGF beta, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls. Furthermore, short-time survivors had the lowest levels of DC markers. Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2011. Vol. 2011, no 212810
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76217DOI: 10.1155/2011/212810ISI: 000298696600001OAI: oai:DiVA.org:liu-76217DiVA: diva2:513031
Note
Funding Agencies|Swedish Research Council|AI52731|Swedish International Development Cooperation Agency (SIDA)||VINN-MER (Vinnova)||Medical Research Council of Southeast Sweden||Swedish Society of Medicine||Foundation for Clinical Cancer Research in Jonkoping, Sweden||Available from: 2012-03-30 Created: 2012-03-30 Last updated: 2017-12-07

Open Access in DiVA

fulltext(6427 kB)778 downloads
File information
File name FULLTEXT01.pdfFile size 6427 kBChecksum SHA-512
d059ffa3e8c00c029c1e56be3d6c710aa39e8af21180b8b2ffe4e468ec0051ebbef63abcc5ae264d5ea1044842bc0718b3afc33eea08a5faab458d9d1e88fd44
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Tjomsland, VegardSandström, PerBorch, KurtLarsson, MarieSpångeus, Anna
By organisation
Molecular VirologyFaculty of Health SciencesSurgeryDepartment of Surgery in ÖstergötlandInternal MedicineDepartment of Endocrinology and Gastroenterology UHL
In the same journal
Clinical & Developmental Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 778 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 133 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf