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A novel blood-based biomarker for detection of autism spectrum disorders
School of Natural Sciences, Linnaeus University, Kalmar, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Department of Clinical Physiology, Kalmar County Hospital, Kalmar, Sweden.
Department of Occupational Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
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2012 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 2, article id e91Article in journal (Refereed) Published
Abstract [en]

Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass–charge (m/z) values of 2020±1, 1864±1 and 1978±1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD.

Place, publisher, year, edition, pages
2012. Vol. 2, article id e91
Keyword [en]
ASD, autism spectrum disorders, biomarker, blood
National Category
Chemical Sciences Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-171076DOI: 10.1038/tp.2012.19ISI: 000315990800007PubMedID: 22832856OAI: oai:DiVA.org:uu-171076DiVA, id: diva2:510184
Funder
Swedish Research Council, 621-2008-3562
Available from: 2012-03-16 Created: 2012-03-15 Last updated: 2017-12-07Bibliographically approved

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