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Nuclisome: targeting the tumor cell nucleus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
2012 (English)In: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 33, no 3, p. 661-667Article in journal (Refereed) Published
Abstract [en]

The Nuclisome concept builds on a novel two-step targeting strategy with the aim to deliver short-range Auger-electron-emitting radionuclides to nuclear DNA of tumor cells. The concept is based on the use of Nuclisome-particles, i.e., tumor-targeted PEG-stabilized liposomes loaded with a unique DNA-intercalating compound that enables specific and effective delivery of radionuclides to DNA. The specific and potent two-step targeting leads to eradication of tumor cells while toxicity to normal organs is reduced to a minimum. Results of in vitro and in vivo studies point towards the Nuclisome concept as a promising strategy for the treatment of small tumor masses and, in particular, for the elimination of spread single cells and micrometastases.

Place, publisher, year, edition, pages
2012. Vol. 33, no 3, p. 661-667
Keywords [en]
Auger, Intercalator, Liposome, Radionuclide, DNA
National Category
Medical and Health Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-168821DOI: 10.1007/s13277-012-0341-3ISI: 000303530200010OAI: oai:DiVA.org:uu-168821DiVA, id: diva2:503569
Available from: 2012-02-16 Created: 2012-02-16 Last updated: 2017-12-07Bibliographically approved

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