Brain electrical impedance at various frequencies: the effect of hypoxia
2004 (English)In: Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, USA • September 1-5, 2004, IEEE Engineering in Medicine and Biology Society , 2004, Vol. 3, 2322-2325 p.Conference paper (Refereed)
Non-invasive multi-frequency measurements of transcephalic impedance, both reactance and resistance, can efficiently detect cell swelling of brain tissue and can be used for early detection of threatening brain damage. We have performed experiments on piglets to monitor transcephalic impedance during hypoxia. The obtained results have confirmed the hypothesis that changes in the size of cells modify the tissue impedance. During tissue inflammation after induced hypoxia, cerebral tissue exhibits changes in both reactance and resistance. Those changes are remarkably high, up to 71% over the baseline, and easy to measure especially at certain frequencies. A better understanding of the electrical behaviour of cerebral tissue during cell swelling would lead us to develop effective non-invasive clinical tools and methods for early diagnosis of cerebral edema and brain damage prevention.
Place, publisher, year, edition, pages
IEEE Engineering in Medicine and Biology Society , 2004. Vol. 3, 2322-2325 p.
, PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, ISSN 1094-687X ; 26, part 1-7
bio-impedance; brain damage; cell swelling; cerebral edema; hypoxia; ischemia; tissue inflammation
Medical Laboratory and Measurements Technologies Signal Processing Neurology
IdentifiersURN: urn:nbn:se:kth:diva-73060DOI: 10.1109/IEMBS.2004.1403674ISI: 000225461800600PubMedID: 17272194ISBN: 0-7803-8439-3OAI: oai:DiVA.org:kth-73060DiVA: diva2:488621
26th Annual International Conference of the IEEE EMBS, San Francisco, CA, SEP 01-05, 2004
Sponsors: Institute of Electrical and Electronics Engineers, IEEE; IEEE Engineering in Medicine and Biology Society.
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QC 201202062012-02-062012-02-012012-02-17Bibliographically approved