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Brain electrical impedance at various frequencies: the effect of hypoxia
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2004 (English)In: Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, USA • September 1-5, 2004, IEEE Engineering in Medicine and Biology Society , 2004, Vol. 3, 2322-2325 p.Conference paper (Refereed)
Abstract [en]

Non-invasive multi-frequency measurements of transcephalic impedance, both reactance and resistance, can efficiently detect cell swelling of brain tissue and can be used for early detection of threatening brain damage. We have performed experiments on piglets to monitor transcephalic impedance during hypoxia. The obtained results have confirmed the hypothesis that changes in the size of cells modify the tissue impedance. During tissue inflammation after induced hypoxia, cerebral tissue exhibits changes in both reactance and resistance. Those changes are remarkably high, up to 71% over the baseline, and easy to measure especially at certain frequencies. A better understanding of the electrical behaviour of cerebral tissue during cell swelling would lead us to develop effective non-invasive clinical tools and methods for early diagnosis of cerebral edema and brain damage prevention.

Place, publisher, year, edition, pages
IEEE Engineering in Medicine and Biology Society , 2004. Vol. 3, 2322-2325 p.
Keyword [en]
bio-impedance; brain damage; cell swelling; cerebral edema; hypoxia; ischemia; tissue inflammation
National Category
Medical Laboratory and Measurements Technologies Signal Processing Neurology
URN: urn:nbn:se:kth:diva-73060DOI: 10.1109/IEMBS.2004.1403674ISI: 000225461800600PubMedID: 17272194ISBN: 0-7803-8439-3OAI: diva2:488621
26th Annual International Conference of the IEEE EMBS, San Francisco, CA, SEP 01-05, 2004
Sponsors: Institute of Electrical and Electronics Engineers, IEEE; IEEE Engineering in Medicine and Biology Society. © 2004 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. QC 20120206Available from: 2012-02-06 Created: 2012-02-01 Last updated: 2012-02-17Bibliographically approved
In thesis
1. Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
Open this publication in new window or tab >>Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
2005 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Electrical bioimpedance spectroscopy is one way to study the electrical properties of biological matter. Different applications of electrical bioimpedance measurements have already been used in both research and clinical scenarios i.e. impedance plethysmography, total body water contents, etc. The electrical properties of tissue reflect the electrical characteristics of the constituent elements of the tissue and depend on its structure. Thus study of the electrical properties not only makes it possible to differentiate among tissues but also to determine the tissue condition. During hypoxia/ischemia the cell activates a certain chain of mechanisms of cellular adaptation in response to the insult. A consequence of these response mechanisms is that the biochemical composition of the cellular environment is altered and the cells swell (cellular edema). These alterations affect the electrical properties of tissue and the changes can be observed through measurement of the electrical bioimpedance of the affected tissue. Based on these ideas, this research work studies the effects of hypoxia/ischemia on the brain electrical impedance. The aim is to obtain the fundamental knowledge that may lead to the development of useful clinical tools for cerebral monitoring based on electrical bioimpedance spectroscopy. 

Place, publisher, year, edition, pages
Gothenburg: Chalmers Reproservice, 2005. 84 p.
, Chalmers Technical Reports, ISSN 1403-266X ; R012/2005
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-80373 (URN)
2015-04-17, EA4, Gothenburg, 13:00 (English)
Brain damage, Detection and localization of cell swelling
QC 20120217Available from: 2012-02-17 Created: 2012-02-09 Last updated: 2012-02-17Bibliographically approved

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