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Spectroscopy study of the dynamics of the transencephalic electrical impedance in the perinatal brain during hypoxia
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2005 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 26, no 5, 849-863 p.Article in journal (Refereed) Published
Abstract [en]

Hypoxia/ischaemia is the most common cause of brain damage in neonates. Thousands of newborn children suffer from perinatal asphyxia every year. The cells go through a response mechanism during hypoxia/ischaemia, to maintain the cellular viability and, as a response to the hypoxic/ischaemic insult, the composition and the structure of the cellular environment are altered. The alterations in the ionic concentration of the intra- and extracellular and the consequent cytotoxic oedema, cell swelling, modify the electrical properties of the constituted tissue. The changes produced can be easily measured using electrical impedance instrumentation. In this paper, we report the results from an impedance spectroscopy study on the effects of the hypoxia on the perinatal brain. The transencephalic impedance, both resistance and reactance, was measured in newborn piglets using the four-electrode method in the frequency range from 20 kHz to 750 kHz and the experimental results were compared with numerical results from a simulation of a suspension of cells during cell swelling. The experimental results make clear the frequency dependence of the bioelectrical impedance, confirm that the variation of resistance is more sensitive at low than at high frequencies and show that the reactance changes substantially during hypoxia. The resemblance between the experimental and numerical results proves the validity of modelling tissue as a suspension of cells and confirms the importance of the cellular oedema process in the alterations of the electrical properties of biological tissue. The study of the effects of hypoxia/ischaemia in the bioelectrical properties of tissue may lead to the development of useful clinical tools based on the application of bioelectrical impedance technology.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2005. Vol. 26, no 5, 849-863 p.
Keyword [en]
bioimpedance; brain damage; cellular oedema; cerebral monitoring; perinatal asphyxia
National Category
Neurology Medical Laboratory and Measurements Technologies Signal Processing
URN: urn:nbn:se:kth:diva-73059DOI: 10.1088/0967-3334/26/5/021ISI: 000232666400022PubMedID: 16088073OAI: diva2:488593
QC 20120208Available from: 2012-02-08 Created: 2012-02-01 Last updated: 2012-02-17Bibliographically approved
In thesis
1. Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
Open this publication in new window or tab >>Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
2005 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Electrical bioimpedance spectroscopy is one way to study the electrical properties of biological matter. Different applications of electrical bioimpedance measurements have already been used in both research and clinical scenarios i.e. impedance plethysmography, total body water contents, etc. The electrical properties of tissue reflect the electrical characteristics of the constituent elements of the tissue and depend on its structure. Thus study of the electrical properties not only makes it possible to differentiate among tissues but also to determine the tissue condition. During hypoxia/ischemia the cell activates a certain chain of mechanisms of cellular adaptation in response to the insult. A consequence of these response mechanisms is that the biochemical composition of the cellular environment is altered and the cells swell (cellular edema). These alterations affect the electrical properties of tissue and the changes can be observed through measurement of the electrical bioimpedance of the affected tissue. Based on these ideas, this research work studies the effects of hypoxia/ischemia on the brain electrical impedance. The aim is to obtain the fundamental knowledge that may lead to the development of useful clinical tools for cerebral monitoring based on electrical bioimpedance spectroscopy. 

Place, publisher, year, edition, pages
Gothenburg: Chalmers Reproservice, 2005. 84 p.
, Chalmers Technical Reports, ISSN 1403-266X ; R012/2005
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-80373 (URN)
2015-04-17, EA4, Gothenburg, 13:00 (English)
Brain damage, Detection and localization of cell swelling
QC 20120217Available from: 2012-02-17 Created: 2012-02-09 Last updated: 2012-02-17Bibliographically approved

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