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IgG Rheumatoid Factors Against the Four Human Fc-gamma Subclasses in Early Rheumatoid Arthritis (The Swedish TIRA Project)
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.ORCID iD: 0000-0002-0153-9249
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2012 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 75, no 1, 115-119 p.Article in journal (Refereed) Published
Abstract [en]

Rheumatoid factor (RF), i.e. a family of autoantibodies against the Fc part of IgG, is an important seromarker of rheumatoid arthritis (RA). Traditional particle agglutination without disclosing the antibody isotype remains the predominating diagnostic method in clinical routine. Although IgG-RF attracts pathogenic interest, its detection remains technically challenging. The present study aimed at developing a set of tests identifying IgG-RFs directed against the four IgG subclasses. IgG-RF against either subclass of human IgG-Fc were analysed with four novel enzyme-linked immunosorbent assays (ELISAs) utilizing four recombinant human Fc-gamma fragments (hIgG14) as sources of antigen. Sera from 40 patients with recent onset RA (20 seropositive and 20 seronegative by IgM-RF and IgA-RF-isotype-specific ELISA) were analysed. Sera from 20 healthy blood donors served as reference. Among the IgM-/IgA-RF-positive RA-sera, IgG-RF was found directed against hIgG1 and hIgG2, but not against hIgG3 or hIgG4. Significant correlations were seen between IgG-RF against hIgG2-Fc and IgM-RF (r = 0.666) levels. Further prospective studies are warranted to elucidate any correlation to disease course and outcome.

Place, publisher, year, edition, pages
Blackwell Publishing , 2012. Vol. 75, no 1, 115-119 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-74430DOI: 10.1111/j.1365-3083.2011.02626.xISI: 000298359200015OAI: oai:DiVA.org:liu-74430DiVA: diva2:484428
Note

Funding Agencies|Swedish foundation for Strategic Research (SSF)||Swedish Research Council (VR)||Swedish Rheumatism Association||King Gustaf Vth 80-year foundation||Research Council of South East Sweden||County Council of Ostergotland||Swedish Society of Medicine||research foundations in memory of Nanna Svartz, Magn||

Available from: 2012-01-27 Created: 2012-01-27 Last updated: 2017-12-08

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Kanmert, DanielKastbom, AlfAlmroth, GunnelSkogh, ThomasEnander, KarinWetterö, Jonas
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