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A disposable and multifunctional capsule for easy operation of microfluidic elastomer systems
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (Mikrosystemteknik)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2011 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 21, no 12, 127001- p.Article in journal (Refereed) Published
Abstract [en]

The global lab-on-chip and microfluidic markets for cell-based assays have been predicted to grow considerably, as novel microfluidic systems enable cell biologists to perform in vitro experiments at an unprecedented level of experimental control. Nevertheless, microfluidic assays must, in order to compete with conventional assays, be made available at easily affordable costs, and in addition be made simple to operate for users having no previous experience with microfluidics. We have to this end developed a multifunctional microfluidic capsule that can be mass-produced at low cost in thermoplastic material. The capsule enables straightforward operation of elastomer inserts of optional design, here exemplified with insert designs for molecular gradient formation in microfluidic cell culture systems. The integrated macro–micro interface of the capsule ensures reliable connection of the elastomer fluidic structures to an external perfusion system. A separate compartment in the capsule filled with superabsorbent material is used for internal waste absorption. The capsule assembly process is made easy by integrated snap-fits, and samples within the closed capsule can be analyzed using both inverted and upright microscopes. Taken together, the capsule concept presented here could help accelerate the use of microfluidic-based biological assays in the life science sector.

Place, publisher, year, edition, pages
Institute of Physics (IOP), 2011. Vol. 21, no 12, 127001- p.
National Category
Other Medical Biotechnology Other Materials Engineering
Research subject
Engineering Science with specialization in Microsystems Technology; Medical Biochemistry
Identifiers
URN: urn:nbn:se:uu:diva-165309DOI: 10.1088/0960-1317/21/12/127001ISI: 000298080100028OAI: oai:DiVA.org:uu-165309DiVA: diva2:472927
Available from: 2012-01-09 Created: 2012-01-04 Last updated: 2017-12-08Bibliographically approved

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Publisher's full texthttp://iopscience.iop.org/0960-1317/21/12/127001

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Thorslund, SaraNguyen, HugoLäräng, ThomasBarkefors, IrmeliKreuger, Johan
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