Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children
2011 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, no 6, 572-577 p.Article in journal (Refereed) Published
It is unknown why allergic symptoms do not develop in all sensitized children. We analyzed prospectively the postnatal secretory IgA (SIgA) development and whether high SIgA levels would protect sensitized infants from developing allergic symptoms. Salivary total IgA and SIgA levels were determined by ELISA, and allergy development was investigated at 3, 6, and 12 mo and at 2 and 5 y in two birth cohorts in Estonia (n = 110) and Sweden (n = 91), two geographically adjacent countries with different living conditions and allergy incidence. Total and SIgA levels increased with age, reaching adult levels at the age of 5. Virtually, all salivary IgA in Estonian children was in the secretory form, while a major part of IgA in Swedish saliva lacked the secretory component up to 2 y of age. In Sweden, high levels of salivary IgA without secretory component correlated inversely with house dust endotoxin levels. High SIgA levels were associated with less development of allergic symptoms in sensitized Swedish children. In conclusion, postnatal maturation of the salivary SIgA system proceeds markedly slower in Swedish than Estonian children, possibly as a consequence of low microbial pressure. SIgA may limit allergy-mediated tissue damage at mucosal surfaces in sensitized individuals.
Place, publisher, year, edition, pages
Nature Publishing Group, 2011. Vol. 70, no 6, 572-577 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-73314DOI: 10.1203/PDR.0b013e318232169eISI: 297433900005PubMedID: 21857384OAI: oai:DiVA.org:liu-73314DiVA: diva2:472077
When submitted this article was titled "Slower maturation of the secretory IgA system in Swedish than Estonian children: possibly caused by low microbial pressure and related to expression of allergy in sensitised individuals".2012-01-032012-01-022013-05-14Bibliographically approved