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A new ultrasound-based approach to visualize target specific polymeric contrast agent
KTH, School of Technology and Health (STH), Medical Engineering.ORCID iD: 0000-0002-4757-7232
KTH, School of Technology and Health (STH), Medical Engineering.
KTH, School of Technology and Health (STH), Medical Engineering.ORCID iD: 0000-0002-5795-9867
Karolinska Institutet.
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2011 (English)In: 2011 IEEE International Ultrasonics Symposium (IUS), IEEE , 2011, 1626-1629 p.Conference paper (Refereed)
Abstract [en]

There are advantages of using a polymeric shelled contrast agent (CA) during ultrasound imaging instead of lipid shelled CA, e.g. particles can be attached to the surface, which enables an introduction of antibodies to the surface making the CA target specific. For this application it is essential to have a sensitive imaging technique suitable for polymeric CA. However, previously presented results have indicated difficulties in visualizing polymeric CA with commercially available contrast algorithms. Therefore a new subtraction algorithm (SA), was developed that define the difference between contrast and reference images. The aim of this study was to evaluate the response from a polymeric CA, when using the SA and compare it with existing contrast algorithms. Moreover, the possibility to detect a thin layer of CA was tested using the SA.

Ultrasound short-axis images of a tissue-mimicking vessel phantom with a pulsating flow were obtained using a GE Vivid7 system (M12L) and a Philips iE33 system (S5-1). Repeated (n=91) contrast to tissue ratios (CTR) calculated at various mechanical index (MI) using the contrast algorithms pulse inversion (PI), power modulation (PM) and SA at a concentration of 105microbubbles/ml.

The developed SA showed improvements in CTR compared to existing contrast algorithms. The CTRs were -0.99 dB ± 0.67 (MI 0.2), 9.46 dB ± 0.77 (MI 0.4) and 2.98 dB ± 0.60 (MI 0.8) with PI, 8.17 dB ± 1.15 (MI 0.2), 15.60 dB ± 1.29 (MI0.4) and 11.60 dB ± 0.73 (MI 0.8) with PM and 14.97 dB ± 3.97 (MI 0.2), 20.89 dB ± 3.54 (MI 0.4) and 21.93 dB ± 4.37 (MI 0.8) with the SA. In addition to this, the layer detection, when using the SA was successful.

Place, publisher, year, edition, pages
IEEE , 2011. 1626-1629 p.
, IEEE International Ultrasonics Symposium, IUS, ISSN 1948-5719
Keyword [en]
Contrast to tissue ratio, Target specific Ultrasound contrast agent, Vessel mimicking phantom
National Category
Medical Image Processing
URN: urn:nbn:se:kth:diva-49538DOI: 10.1109/ULTSYM.2011.0404ISI: 000309918400385ScopusID: 2-s2.0-84869054266ISBN: 978-1-4577-1252-4OAI: diva2:459769
2011 IEEE International Ultrasonics Symposium, IUS 2011; Orlando, FL;18 October 2011 through 21 October 2011

© 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. QC 20111202

Available from: 2011-12-02 Created: 2011-11-28 Last updated: 2013-01-08Bibliographically approved

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