Patient-Specific Modeling and Simulation of Deep Brain Stimulation
2011 (English)In: Patient-Specific Modeling in Tomorrow's Medicine / [ed] Amit Gefen, Springer Berlin/Heidelberg, 2011, 357-378 p.Chapter in book (Refereed)
Deep brain stimulation (DBS) is widely used for reduction of symptoms caused by movement disorders. In this chapter a patient-specific finite element method for modeling and simulation of DBS electric parameters is presented. The individual’s stereotactic preoperative MR-batch of images is used as input to the model in order to classify tissue type and allot electrical conductivity for cerebrospinal fluid, blood and grey as well as white matter. With patient-specific positioning of the DBS electrodes the method allows for investigation of the relative electric field changes in relation to anatomy and DBS-settings. Examples of visualization of the patient-specific electric entities together with the surrounding anatomy are given. The use of the method is exemplified on patients with Parkinson’s disease. Future applications including multiphysics simulations and applicability for new DBS targets and symptoms are discussed.
Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2011. 357-378 p.
, Studies in mechanobiology, tissue engineering and biomaterials, ISSN 1868-2006 ; 9
Other Medical Engineering
IdentifiersURN: urn:nbn:se:liu:diva-72087DOI: 10.1007/8415_2011_104ISBN: 978-3-642-24617-3OAI: oai:DiVA.org:liu-72087DiVA: diva2:456899