Biocompatible X-ray opaque polymers for medical devices
Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
During coronary catheterization X-ray imaging is used to image coronary artery system. After the procedure X-ray imaging may be used to locate devices purposely left in the patient. The objective of this thesis was to investigate the possibility of improving X-ray opacity to medical devices made by St Jude Medical Systems AB. Two different routes were explored, inorganic-organic hybrid materials and functionalization of polymers with iodine. Sol-Gel synthesis was used to synthesize nanocomposite hybrid materials with TiO2 and Ta2O5. Iodine was incorporated by the use of an iodine containing initiator and by end group functionalization with triiodobenzoic acid. The materials were evaluated by X-ray imaging, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscopy (SEM). The optical and mechanical properties were evaluated by visual inspection and by handling of the materials. Hybrid materials with Polydimetylsiloxane (PDMS) or Poly ester copolymers and Ta2O5 were found to have promising mechanical properties and degree of X-ray opacity. Iodinated polyesters with ~18 wt% iodine also demonstrated sufficient properties to promote further investigation. Some of the work done and obtained results has been excluded from this report due to patent applications.
Place, publisher, year, edition, pages
2011. , 38 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-44036OAI: oai:DiVA.org:kth-44036DiVA: diva2:449152
Subject / course
Weissenrieder, Jonas, Forskarass.