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Leucine intake affects brain activity and central expression of genes associated with food intake, energy homeostasis and reward.
Mälardalen University, School of Sustainable Development of Society and Technology.
2011 (English)Independent thesis Basic level (university diploma), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Leucine injections directly into the brain decrease food intake whereas supplementation of this amino acid in a diet has a negligible effect on food intake. We sought to investigate why orally supplemented leucine is ineffective as an anorexigen. We found that mice consuming leucine exhibited increased cFos immunoreactivity in the ARC and PVN of hypothalamus, areas controlling energy balance. However, real time- PCR analysis of the hypothalamic tissue in mice that were exposed to oral leucine showed changes in expression of genes involved in the regulation of energy balance as well as those mediating feeding reward (TMEM18, MC4R, CRH, FTO, SLC6A15, DOR). This suggests that leucine consumption affects activity of not only brain pathways that control calorie intake, but also those that mediate eating for pleasure. Hence the lack of feeding response to leucine supplementation in a diet may stem from the simultaneous action of this amino acid at brain circuit promoting reward and energy homeostasis.

Place, publisher, year, edition, pages
2011. , 13 p.
Keyword [en]
food intake, reward, leucine
National Category
Medical and Health Sciences
URN: urn:nbn:se:mdh:diva-13104OAI: diva2:447251
Subject / course
Chemical Engineering
Life Earth Science
Available from: 2011-10-12 Created: 2011-10-11 Last updated: 2011-10-12Bibliographically approved

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Johansson, Alina
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