Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Molecular phenotypes of unifocal, multifocal, and diffuse invasive breast carcinomas.
Show others and affiliations
2011 (English)In: Pathology research international, ISSN 2042-003X, Vol. 2011, 480960- p.Article in journal (Refereed) Published
Abstract [en]

We analyzed the subgross distribution of the invasive component in 875 consecutive cases of breast carcinomas using large-format histology sections and compared the immunophenotype (estrogen and progesterone receptor expression, HER2 overexpression and expression of basal-like markers, CK5/6, CK14, and epidermal growth factor receptor) in unifocal, multifocal, and diffuse tumors. Histology grade and lymph node status were also analyzed. Unifocal invasive carcinomas comprised 58.6% (513/875), multifocal invasive carcinomas 36.5% (319/875), and diffuse invasive carcinomas 4.9% (43/875) of the cases. The proportion of lymph node-positive cases was significantly higher in multifocal and diffuse carcinomas compared to unifocal cancers, but no other statistically significant differences could be verified between these tumor categories. Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype.

Place, publisher, year, edition, pages
Sage-Hindawi , 2011. Vol. 2011, 480960- p.
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:umu:diva-48186DOI: 10.4061/2011/480960PubMedID: 21151538OAI: oai:DiVA.org:umu-48186DiVA: diva2:446963
Available from: 2011-10-11 Created: 2011-10-10 Last updated: 2011-11-16Bibliographically approved

Open Access in DiVA

fulltext(1702 kB)259 downloads
File information
File name FULLTEXT02.pdfFile size 1702 kBChecksum SHA-512
d4efd38839557e9dda5adecd3e11e4af11db324b28031434ab69637cd3c0c12a577d24b15205e12fee5cb2ebe6241f08f257d234b5478828550781b1306a4af2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindquist, David
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 259 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 132 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf