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Deep brain stimulation of caudal zona incerta and subthalamic nucleus in patients with Parkinson’s disease: effects on diadochokinetic rate
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
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2011 (English)In: Parkinson’s Disease, ISSN 2042-0080, Vol. 2011, 605607- p.Article in journal (Refereed) Published
Abstract [en]

The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2011. Vol. 2011, 605607- p.
National Category
Neurology
Research subject
Linguistics; Neurosurgery; Neurology
Identifiers
URN: urn:nbn:se:umu:diva-48157DOI: 10.4061/2011/605607OAI: oai:DiVA.org:umu-48157DiVA: diva2:446883
Projects
Effekter av djup hjärn-stimulering på tal hos Parkinsonpatienter
Funder
Swedish Research Council, 2009-946
Available from: 2012-04-13 Created: 2011-10-10 Last updated: 2012-06-04Bibliographically approved

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Karlsson, FredrikUnger, ElinWahlgren, SofiaBlomstedt, PatricLinder, JanNordh, ErikZafar, HamayunDoorn, Jan van
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