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In-vitro study of antibiotic and strontium release from hydroxyapatite spheres and its PMMA composite
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
2011 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The aim of this project was to study the in vitro release of cephalothin, vancomycin and strontium from hydroxyapatite particles and its PMMA composite. The hydroxyapatite spheres containing strontium were prepared in the laboratory. The in vitro release study for the hydroxyapatite was carried out in phosphate buffer saline solution (PBS) with differing pH value at 37 °C for five days and the PMMA composites for 21 days.

All of the releases showed a burst release within the first 24 hours followed by a slow release. The pH value of the release medium had influence on the release rate to some extent for the antibiotic release and the acidic solution had a more significant impact on the strontium release. All of the composite groups had a much lower strontium release rate than the strontium release from the hydroxyapatite spheres.

Place, publisher, year, edition, pages
2011. , 24 p.
UPTEC K, ISSN 1650-8297 ; 11025
Keyword [en]
In vitro, antibiotic, strontium, hydroxyapatite, PMMA
National Category
Chemical Engineering
URN: urn:nbn:se:uu:diva-159541OAI: diva2:445434
Subject / course
Educational program
Master Programme in Chemical Engineering
Available from: 2012-10-24 Created: 2011-10-04 Last updated: 2012-10-24Bibliographically approved

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