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A hybrid systems framework for cellular processes
KTH, School of Electrical Engineering (EES), Automatic Control.ORCID iD: 0000-0001-9940-5929
2005 (English)In: Biosystems (Amsterdam. Print), ISSN 0303-2647, E-ISSN 1872-8324, Vol. 80, no 3, 273-282 p.Article in journal (Refereed) Published
Abstract [en]

With the availability of technologies that allow us to obtain stimulus-response time series data for modeling and system identification, there is going to be an increasing need for conceptual frameworks in which to formulate and test hypotheses about intra- and inter-cellular dynamics, in general and not just dependent on a particular cell line, cell type, organism, or technology. While the semantics can be quite different, biologists and systems scientists use in many cases a similar language (notion of feedback, regulation, etc.). A more abstract system-theoretic framework for signals, systems, and control could provide the biologist with an interface between the domains. Apart from recent examples to identify functional elements and describing them in engineering terms, there have been various more abstract developments to describe dynamics at the cell level in the past. This includes Rosen's (M,R)-systems. This paper presents an abstract and general compact mathematical framework of intracellular dynamics, regulation and regime switching inspired by (M,R)-theory and based on hybrid automata.

Place, publisher, year, edition, pages
2005. Vol. 80, no 3, 273-282 p.
Keyword [en]
systems biology, cellular processes, (M, R)-theory, dynamical model, hybrid automata
National Category
Control Engineering
URN: urn:nbn:se:kth:diva-37807DOI: 10.1016/j.biosystems.2004.12.002ISI: 000229529900005ScopusID: 2-s2.0-18844431307OAI: diva2:435245
QC 20110817Available from: 2011-08-17 Created: 2011-08-17 Last updated: 2012-01-31Bibliographically approved

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