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Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology.
2011 (English)In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ISSN 1046-7408, Vol. 66, 31-43 p.Article, review/survey (Refereed) Published
Abstract [en]

Problem During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus. Method In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance. Results Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in nonpregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy. Conclusion Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 66, 31-43 p.
Keyword [en]
Cytokines; reproductive immunology; T helper cell; tolerance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-69811DOI: 10.1111/j.1600-0897.2011.01049.xISI: 000292337700005OAI: oai:DiVA.org:liu-69811DiVA: diva2:433550
Note

This is the authors’ version of the publication: Jan Ernerudh, Göran Berg and Jenny Mjösberg, Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance, 2011, AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, (66), 31-43. http://dx.doi.org/10.1111/j.1600-0897.2011.01049.x Copyright: John Wiley and Sons http://www.wiley.com/

Available from: 2011-08-10 Created: 2011-08-08 Last updated: 2013-11-07

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Ernerudh, JanBerg, GöranMjösberg, Jenny
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Clinical ImmunologyFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion MedicineObstetrics and gynecologyDepartment of Gynaecology and Obstetrics in Linköping
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