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Differences in presentation of symptoms between women and men with intermittent claudication
Karolinska Institute.
Karlstad Hospital.
Karlstad Hospital .
University Uppsala Hospital.
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2011 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, Vol. 11, no 39Article in journal (Refereed) Published
Abstract [en]

Background: More women than men have PAD with exception for the stage intermittent claudication (IC). The purpose of this study was to evaluate differences in disease characteristics between men and women when using current diagnostic criteria for making the diagnosis IC, defined as ABI less than 0.9 and walking problems. Study Design: Cohort study Methods: 5040 elderly (median age 71) subjects participated in a point-prevalence study 2004. They had their ABI measured and filled out questionnaires covering medical history, current medication, PAD symptoms and walking ability. The prevalence of IC was 6.5% for women and 7.2% for men (P = 0.09). A subset of subjects with IC (N = 56) was followed up four years later with the same procedures. They also performed additional tests aiming to determine all factors influencing walking ability. Results: Men with IC had more concomitant cardiovascular disease and a more profound smoking history than women. Women, on the other hand, reported a lower walking speed (P less than 0.01) and more joint problems (P = 0.018). In the follow up cohort ABI, walking ability and amount of atherosclerosis were similar among the sexes, but women more often reported atypical IC symptoms. Conclusion: Sex differences in the description of IC symptoms may influence diagnosis even if objective features of PAD are similar. This may influence accuracy of prevalence estimates and selection to treatment.

Place, publisher, year, edition, pages
BioMed Central , 2011. Vol. 11, no 39
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-69845DOI: 10.1186/1471-2261-11-39ISI: 000292822300001OAI: diva2:433450
Original Publication: Birgitta Sigvant, Fredrik Lundin, Bo Nilsson, David Bergqvist and Eric Wahlberg, Differences in presentation of symptoms between women and men with intermittent claudication, 2011, BMC Cardiovascular Disorders, (11), 39. Licensee: BioMed Central Available from: 2011-08-10 Created: 2011-08-08 Last updated: 2012-03-15

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Faculty of Health SciencesDepartment of Thoracic and Vascular Surgery in ÖstergötlandThoracic Surgery
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