Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Delayed Development of Visuomotor Capacity in Very Preterm Infants
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Endokrin)
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

To coordinate visual perception and motor control in daily life where we are constantly surrounded by motion, we are dependent on normal visuomotor capacity. One essential prerequisite for normal visuomotor capacity is smooth pursuit eye movements (SP). Infants born very preterm (VPT = born <32 gestational weeks) are at high risk of developing disabilities in higher brain functions i.e. perception, cognition, concentration and coordination.

In this thesis visuomotor capacity was investigated in a cohort of VPT infants (n = 113) and compared to control groups of full term (FT) infants. Levels of SP were measured at 2 and 4 months’ corrected age (CA). At 8 months’ CA reaching capacity toward a moving object was evaluated as this represents an executive activity guided by vision that develops at an early age.

Lower levels of SP were found in the VPT infants compared to FT controls. The VPT boys showed higher levels of SP compared to the VPT girls.

In VPT infants without major neonatal morbidities lower levels of SP was found compared to the FT controls. No difference in total capacity of gaze tracking was found, although the VPT infants lagged the object more at 4 months’ CA and used more saccades at 2 months’ CA.

With age the VPT infants’ SP levels increased, but with a wider dispersion compared to the FT controls, and the levels of SP at 4 months’ CA corresponded to the levels of the FT infants at 2 months.

 A number of perinatal risk factors were found to be negatively associated to lower levels of SP, and this effect was more pronounced in VPT infants with multiple risk factors,.

 When evaluating the capacity to reach a moving object at 8 months’ CA, the VPT infants showed significantly more bimanual reach and more curved reaching paths to catch the object as compared to the FT control group.

In conclusion, a delayed visuomotor capacity was found in VPT infants compared to FT control infants at 2, 4 and 8 months’ CA. Some VPT infants with perinatal risk factors did not develop in levels of SP between 2 and 4 months’ CA.

 

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2011. , 58 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 681
Keyword [en]
preterm infants, visual development, neurosensory development, smooth pursuit eye movements, perinatal risk factors, reaching movements
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-156518ISBN: 978-91-554-8110-0 (print)OAI: oai:DiVA.org:uu-156518DiVA: diva2:432035
Public defence
2011-09-15, Rosénsalen, Ing 95/96 NBV, Kvinno-och Barndivisionen, Akademiska sjukhuset, Uppsala, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2011-08-25 Created: 2011-07-28 Last updated: 2011-09-08Bibliographically approved
List of papers
1. Development of smooth pursuit eye movements in very preterm infants: 1. General aspects
Open this publication in new window or tab >>Development of smooth pursuit eye movements in very preterm infants: 1. General aspects
Show others...
2011 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 100, no 7, 983-991 p.Article in journal (Refereed) Published
Abstract [en]

Aim:  To investigate early oculo-motor development in a population-based cohort of very preterm infants.

Methods:  Early oculo-motor development was prospectively studied by measuring smooth pursuit eye movements at 2 and 4 months corrected age in a population of very preterm infants born in Uppsala County 2004–2007. Eighty-one preterm infants were studied, and 32 healthy term infants constituted the control group.

Results:  The study group consisted of infants with a mean gestational age of28 + 5 weeks. At 2 and 4 months corrected age, infants born very preterm showed lower gain (p < 0.001) and proportion of smooth pursuit eyemovements (p < 0.001) compared to the control group. The boys showed higher gain of smooth pursuit eye movements at both 2 and 4 months corrected age, compared to girls.

Conclusions:  Oculo-motor development measured by smooth pursuit eye movements is delayed in very preterm infants at 2 and 4 months corrected age. This might be a risk factor or early indicator of later perceptual and behavioural impairment.

Keyword
Infant development, Oculo-motor, Preterm infant, Smooth pursuit eye movements
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-155277 (URN)10.1111/j.1651-2227.2011.02218.x (DOI)000291224200025 ()
Note

Titel på manuskript i avhandling: Delayed development of smooth pursuit eye movements in very preterm born infants. A Longitudinal Study of VISuomotor capacity (“LOVIS”)

Available from: 2011-06-20 Created: 2011-06-20 Last updated: 2017-12-11Bibliographically approved
2. Development of Smooth Pursuit Eye Movements in very preterm born infants: 3. Association to perinatal risk factors
Open this publication in new window or tab >>Development of Smooth Pursuit Eye Movements in very preterm born infants: 3. Association to perinatal risk factors
Show others...
2012 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 101, no 2, 164-171 p.Article in journal (Refereed) Published
Abstract [en]

Aim:  To investigate the association between perinatal risk factors and neonatal complications and early oculo-motor development in very preterm infants.

Methods:  Perinatal risk factors were identified, and the potential association with early oculo-motor development was evaluated by measuring smooth pursuit eye movements (SP) at 2 and 4 months' corrected age (CA) in a population of very preterm infants born in Uppsala County 2004-2007 (n = 113).

Results:  Among the 15 tested factors, eight showed significant association in univariate analysis with lower levels of SP at 4 months' CA, namely administration of prenatal corticosteroids, gestational age, birthweight, bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular haemorrhage >grade 2, and persistent ductus arteriosus. At 2 months' CA, only retinopathy of prematurity >stage 2 was associated with lower levels of SP. When all factors significant in the univariate tests were included in multiple regressions aimed to assess each factor's independent relation to SP, periventricular leukomalacia was the only significant independent factor. When adding 2-5 of the significant factors using multiple regression analysis, the levels of SP became lower.

Conclusion:  Perinatal risk factors were associated with lower levels of SP. This could be interpreted as delayed or disturbed development of normal oculomotor ability.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-155199 (URN)10.1111/j.1651-2227.2011.02449.x (DOI)000298914000021 ()21883450 (PubMedID)
Available from: 2011-06-20 Created: 2011-06-20 Last updated: 2017-12-11Bibliographically approved
3. Development of smooth pursuit eye movements in very prematurely born infants: 2. The low-risk subgroup.
Open this publication in new window or tab >>Development of smooth pursuit eye movements in very prematurely born infants: 2. The low-risk subgroup.
2011 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 100, no 7, e5-e11 p.Article in journal (Refereed) Published
Abstract [en]

Aim:  To investigate the impact of premature birth on visual tracking in a group of 37 infants, born before the 32nd gestational weeks (mean 29 + 6 weeks) and diagnosed as being without major neonatal complications. This paper is a part of the LOVIS study (Strand Brodd, Ewald, Grönqvist, Holmström, Strömberg, Von Hofsten, et al. Acta Pediatrica, 2011). Methods:  At 2 and 4 months corrected age, eye and head movements were measured when the infant tracked a moving object. The eye movements were analysed in terms of smooth pursuit and saccades (Vision Res, 37, 1997, 1799; Exp Brain Res, 146, 2002, 257). Accuracy of gaze, proportion of smooth pursuit, head movements and saccades were calculated. Results:  Between 2 and 4 months of age, all infants improved their ability to smoothly pursue a moving object. However, at both occasions, the preterm infants had less proportion smooth pursuit than the full-term infants. The groups did not differ with respect to gaze and head movements, but the saccade frequency was higher for the very preterms in some of the conditions. Conclusion:  The development of smooth pursuit in the low-risk preterm infant group was strongly delayed compared to typically developed infants. Thus, the 2 months or more extra visual experience did not have a distinguishable positive effect on visuo-motor development as expressed in smooth pursuit.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-155197 (URN)10.1111/j.1651-2227.2011.02247.x (DOI)000291224200007 ()21362038 (PubMedID)
Note

Manuskriptets titel i avhandlingen: Delayed development of smooth pursuit in very preterm infants with low risk

Available from: 2011-06-20 Created: 2011-06-20 Last updated: 2017-12-11Bibliographically approved
4.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

Open Access in DiVA

fulltext(4267 kB)789 downloads
File information
File name FULLTEXT01.pdfFile size 4267 kBChecksum SHA-512
83586f47e539ccb32e241bc0871dc0e67652dda6b600fdf4516aac23ffd8061a8f2342db238d873f4fde64f04489deb7b691a3b353cfcdb636c901ff41860390
Type fulltextMimetype application/pdf
Buy this publication >>

Search in DiVA

By author/editor
Strand Brodd, Katarina
By organisation
Pediatrics
Pediatrics

Search outside of DiVA

GoogleGoogle Scholar
Total: 789 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 638 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf