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A Comparison of Two Immunoturbidimetric Assay Methods for Serum Amyloid A in Cats.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2011 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

The analysis of acute phase protein serum amyloid A (SAA) has recently been brought into clinical use in veterinary medicine. Some of the difficulties with incorporating the SAA method in clinical practice have been the expensive and rather large equipment required for the method. Due to these difficulties only larger clinics can afford to use the SAA analysis.

The company Equinostic has recently developed a smaller instrument that costs one-tenth of a larger instrument. The instrument is named EVA1 and has so far only been used to analyze SAA in horses.

The aim of this study was to investigate if the EVA1 instrument could be used to analyze SAA in cats. This study included 24 serum samples from cat, which were first analyzed twice on the EVA1 instrument and then sent to the Strömsholm Referral Animal Hospital in Sweden where they reanalyzed the samples using a validated reference method. Both instruments are based on an immunoturbidimetric assay.

The correlation between the two instruments was good (r=0.97) but the EVA1 instrument showed constantly lower results than the reference method. The difference between the duplicates when analyzed on the EVA1 instrument was larger than expected.

The conclusion is that EVA1 could be used to analyze SAA in cats. However, before it could be used clinically in veterinary practice an extended study is recommended.

Place, publisher, year, edition, pages
2011. , 12 p.
Keyword [en]
Correlation, SAA, Feline, Acute phase proteins (APP), Acute phase reaction (APR).
Keyword [sv]
Korrelation, SAA, Feline, Akutfasprotein (APP), Akutfasreaktion (APR).
National Category
Other Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-154803OAI: oai:DiVA.org:uu-154803DiVA: diva2:422355
Educational program
Biomedicinska analytikerprogrammet
Uppsok
Medicine
Supervisors
Examiners
Available from: 2011-06-17 Created: 2011-06-12 Last updated: 2011-06-17Bibliographically approved

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Edblom, Sara
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