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Tumour Necrosis Factor in the Canine Endometrium: An Immunohistochemical Study
University Tras os Montes and Alto Douro.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Medical Genetics.ORCID iD: 0000-0002-5194-2124
2011 (English)In: REPRODUCTION IN DOMESTIC ANIMALS, ISSN 0936-6768, Vol. 46, no 3, 410-418 p.Article in journal (Refereed) Published
Abstract [en]

Contents Tumour necrosis factor (TNF), a pleiotropic cytokine that regulates cell growth and differentiation as well as the synthesis of other cytokines, has been identified in the uterus of several species describing a cyclic pattern, eventually under ovarian steroid regulation. Information is yet limited on the presence of TNF protein in the canine endometrium during the oestrous cycle and early pregnancy. This study depicts the temporal immunolocalization of TNF in the bitch endometrium along the oestrous cycle and changes associated with the early steps of embryo invasion. TNF immunolabelling was found in both the stromal fibroblasts and epithelial components of the canine endometrium in all stages studied. Stromal immunostaining was more intense than that of the epithelia, in all the stages of the oestrous cycle. In addition, a tendency for a decrease in the surface epithelium intensity score was found in early dioestrus. A positive glandular content was only observed in anoestrus and proestrus stages. In early pregnancy (days 13-16), TNF immunolabelling was detected at the embryo-maternal surface, in the syncytium cords and the trophoblast, as well in the endometrial stroma and the basal endometrial glands, but not in the lacunar epithelium. The overall TNF immunoreactivity was higher in early pregnancy samples in comparison with those of the early dioestrus and dioestrus stages, suggesting it plays a role during implantation.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 46, no 3, 410-418 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-68681DOI: 10.1111/j.1439-0531.2010.01681.xISI: 000290266600005OAI: diva2:419720
This is the authors’ version of the following article: R Payan-Carreira, M A Pires and Heriberto Rodriguez-Martinez, Tumour Necrosis Factor in the Canine Endometrium: An Immunohistochemical Study, 2011, REPRODUCTION IN DOMESTIC ANIMALS, (46), 3, 410-418. which has been published in final form at: Copyright: Blackwell Publishing Ltd from: 2011-05-27 Created: 2011-05-27 Last updated: 2015-03-12

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