Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.ORCID iD: 0000-0002-3576-2393
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Show others and affiliations
2004 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 10, no 5, p. 494-501Article in journal (Refereed) Published
Abstract [en]

Recent studies have suggested that bone marrow cells might possess a much broader differentiation potential than previously appreciated. In most cases, the reported efficiency of such plasticity has been rather low and, at least in some instances, is a consequence of cell fusion. After myocardial infarction, however, bone marrow cells have been suggested to extensively regenerate cardiomyocytes through transdifferentiation. Although bone marrow-derived cells are already being used in clinical trials, the exact identity, longevity and fate of these cells in infarcted myocardium have yet to be investigated in detail. Here we use various approaches to induce acute myocardial injury and deliver transgenically marked bone marrow cells to the injured myocardium. We show that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium. Engraftment was transient, however, and hematopoietic in nature. In contrast, bone marrow-derived cardiomyocytes were observed outside the infarcted myocardium at a low frequency and were derived exclusively through cell fusion.

Place, publisher, year, edition, pages
2004. Vol. 10, no 5, p. 494-501
Keywords [en]
Animals, Cell Differentiation, Cell Fusion, Cell Movement, Graft Survival, Green Fluorescent Proteins, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Lac Operon, Luminescent Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myocardial Infarction, Myocytes, Cardiac, Recombinant Proteins
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-15178DOI: 10.1038/nm1040PubMedID: 15107841Scopus ID: 2-s2.0-2442675144OAI: oai:DiVA.org:hh-15178DiVA, id: diva2:419616
Available from: 2011-05-27 Created: 2011-05-27 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Nygren, Jens Martin
In the same journal
Nature Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 116 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf