Anabaena sensory rhodopsin is a light-driven unidirectional rotor
2010 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 107, no 50, 21322-21326 p.Article in journal (Refereed) Published
The implementation of multiconfigurational quantum chemistry methods into a quantum-mechanics/molecular-mechanics protocol has allowed the construction of a realistic computer model for the sensory rhodopsin of the cyanobacterium Anabaena PCC 7120. The model, which reproduces the absorption spectra of both the all-trans and 13-cis forms of the protein and their associated K and L intermediates, is employed to investigate the light-driven steps of the photochromic cycle exhibited by the protein. It is found that the photoisomerizations of the all-trans and 13-cis retinal chromophores occur through unidirectional, counterclockwise 180 deg rotations of the =C14-C15= moiety with respect to the Lys210-linked end of the chromophore axis. Thus, the sequential interconversions of the all-trans and 13-cis forms during a single photochromic cycle yield a complete (360 deg) unidirectional rotation of the =C14-C15= moiety. This finding implies that Anabaena sensory rhodopsin is a biological realization of a light-driven molecular rotor.
Place, publisher, year, edition, pages
National Academy of Sciences of the United States of America , 2010. Vol. 107, no 50, 21322-21326 p.
Molecular motors, Molecular modeling, Photoreceptors, Stereochemistry, Chirality
IdentifiersURN: urn:nbn:se:liu:diva-68232DOI: 10.1073/pnas.1015085107OAI: oai:DiVA.org:liu-68232DiVA: diva2:416927
Angela Strambi, Bo Durbeej, Nicolas Ferre and Massimo Olivucci, Anabaena sensory rhodopsin is a light-driven unidirectional rotor, 2010, Proceedings of the National Academy of Sciences of the United States of America, (107), 50, 21322-21326.
Copyright: National Academy of Sciences; 1999