Wnt signaling and orthopedics, an overview
2011 (English)In: ACTA ORTHOPAEDICA, ISSN 1745-3674, Vol. 82, no 2, 125-130 p.Article in journal (Refereed) Published
Wnt signaling is a ubiquitous system for intercellular communication, with multiple functions during development and in homeostasis of the body. It comprises several ligands, receptors, and inhibitors. Some molecules, such as sclerostin, appear to have bone-specific functions, and can be targeted by potential drugs. Now, ongoing clinical trials are testing these drugs as treatments for osteoporosis. Animal studies have also suggested that these drugs can accelerate fracture healing and implant fixation. This brief overview focuses on currently available information on the effects of manipulations of Wnt signaling on bone healing.
Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 82, no 2, 125-130 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67742DOI: 10.3109/17453674.2011.572252ISI: 000289170900001OAI: oai:DiVA.org:liu-67742DiVA: diva2:412626
Fredrik Agholme and Per Aspenberg, Wnt signaling and orthopedics, an overview, 2011, ACTA ORTHOPAEDICA, (82), 2, 125-130.
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