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Local Heating as a Predilatation Method for Measurement of Vasoconstrictor Responses with Laser-Doppler Flowmetry
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Burn Center. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Surgery.
2011 (English)In: Microcirculation, ISSN 1073-9688, Vol. 18, no 3, 214-220 p.Article in journal (Refereed) Published
Abstract [en]

Studying microvascular responses to iontophoresis of vasoconstricting drugs contributes to a better understanding of the regulatory mechanisms of cutaneous vessels, but measuring these responses with laser-Doppler flowmetry at basal blood flow conditions is technically challenging. This study aimed to investigate whether the measurement of cutaneous vasoconstrictor responses to noradrenaline (NA) and phenylephrine (PE), delivered by iontophoresis, is facilitated by predilatation of the microvascular bed using local heating. We used different drug delivery rates (100 s x 0.12 mA, 200 s x 0.06 mA, 300 s x 0.04 mA) to investigate whether predilatation affects the local drug dynamics by an increased removal of drugs from the skin. In a predilatated vascular bed, iontophoresis of NA and PE resulted in a significant decrease in perfusion from the thermal plateau (p andlt; 0.001). The decrease was 25-33%, depending on drug delivery rate. In unheated skin, a significant vasoconstriction was observed (p andlt; 0.001), with 17% and 14% decrease from baseline for NA and PE, respectively. These results indicate that predilatating the cutaneous vascular bed by local heating facilitates measurement of vasoconstriction with laser-Doppler flowmetry and does not seem to significantly affect the result by an increased removal of drugs from the skin.

Place, publisher, year, edition, pages
John Wiley & Sons, 2011. Vol. 18, no 3, 214-220 p.
Keyword [en]
iontophoresis, laser-Doppler, vasoconstriction, local heating, adrenoceptors
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-67553DOI: 10.1111/j.1549-8719.2010.00079.xISI: 000288759900006PubMedID: 21199093OAI: oai:DiVA.org:liu-67553DiVA: diva2:411252
Note

Original Publication: Joakim Henricson, Yashma Baiat and Folke Sjöberg, Local Heating as a Predilatation Method for Measurement of Vasoconstrictor Responses with Laser-Doppler Flowmetry, 2011, MICROCIRCULATION, (18), 3, 214-220. http://dx.doi.org/10.1111/j.1549-8719.2010.00079.x Copyright: Wiley http://eu.wiley.com/WileyCDA/Brand/id-35.html

Available from: 2011-04-18 Created: 2011-04-18 Last updated: 2014-06-12Bibliographically approved

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Henricson, JoakimSjöberg, Folke
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SurgeryFaculty of Health SciencesDepartment of Biomedical EngineeringThe Institute of TechnologyBurn CenterDepartment of Hand and Plastic SurgeryDepartment of Anaesthesiology and Surgery
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