Change search
ReferencesLink to record
Permanent link

Direct link
Oral-parenteral conversion factor for morphine in palliative cancer care: a prospective randomized crossover pilot study
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
2011 (English)In: Pain Research and Treatment, ISSN 2090-1550, 504034- p.Article in journal (Refereed) Published
Abstract [en]

Objective. This pilot study clinically tests whether a conversion factor of 2 to 1 is appropriate when changing from oral to parenteral morphine administration in the treatment of cancer-related nociceptive pain and calculates the size of an adequately powered future study.

Methods. Eleven outpatients with incurable cancer and well-controlled nociceptive pain were randomly assigned to either intravenous or subcutaneous morphine using half the previous oral 24-hour dose. Each group crossed over after the first three-day period. Serum concentrations of morphine and its metabolites were monitored as well as intensity of pain.

Results. Oral to subcutaneous and oral to intravenous quotas of morphine concentrations were approximately 0.9. Subcutaneous to intravenous morphine quotas were 1.

Conclusions. The conversion factor of 2 to 1 seems to be a reasonable average but with an obvious need for individual adjustments. Concurrent medications and substantially higher doses of morphine could potentially affect the appropriate conversion factor. An adequately powered study to validate these findings would need at least 121 patients.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2011. 504034- p.
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-42442DOI: 10.1155/2011/504034OAI: diva2:409254
Available from: 2011-04-07 Created: 2011-04-07 Last updated: 2012-08-09Bibliographically approved

Open Access in DiVA

fulltext(164 kB)107 downloads
File information
File name FULLTEXT02.pdfFile size 164 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Jonsson, HåkanAxelsson, Bertil
By organisation
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 107 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 68 hits
ReferencesLink to record
Permanent link

Direct link