The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: A cross-sectional study.
2011 (English)In: jraas. Journal of the renin-angiotensin-aldosterone system, ISSN 1470-3203, E-ISSN 1752-8976, Vol. 12, no 3, 281-289 p.Article in journal (Refereed) Published
INTRODUCTION: A polymorphism in the angiotensin-converting enzyme gene (ACE I/D polymorphism) has been associated with increased risk for cardiovascular disease (CVD). This polymorphism affects the level of circulating ACE, but there is great individual variation, even between those with the same genotype. Few previous studies have investigated the link between circulating ACE and cardiovascular risk. The aim of this study was to investigate this association, and to examine the relationship between ACE level, ACE genotype and CVD.
MATERIALS AND METHODS: The study population consisted of 322 men and 350 women aged 69-87. Plasma ACE level was determined using enzyme-linked immunosorbent assay (ELISA), and ACE genotype was analysed using PCR followed by gel electrophoresis.
RESULTS: In men, ACE levels increased with increasing number of cardiovascular risk factors (p = 0.003). There was a significant association in men between increased ACE level and both diabetes (p = 0.007) and smoking (p = 0.037).
CONCLUSIONS: This study shows that cardiovascular risk factors (such as smoking and diabetes) are associated with higher levels of circulating ACE in men. High ACE levels may represent one of the cellular mechanisms involved in producing the vascular damage associated with cardiovascular risk factors.
Place, publisher, year, edition, pages
SAGE , 2011. Vol. 12, no 3, 281-289 p.
Cardiovascular risk factors, dibetes, endothelium, genetics, smoking
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67208DOI: 10.1177/1470320310391326ISI: 000294450600019PubMedID: 21273224OAI: oai:DiVA.org:liu-67208DiVA: diva2:408311
Funding Agencies|Cardiovascular Inflammatory Research Center, Linkoping, Sweden||Swedish Research Council|
|Elanora Demeroutis Foundation, Linkoping, Sweden|
|Goljes Memorial Foundation, Sweden|
|Medical Research Council of South East Sweden|