Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry. (Hammarström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry. (Hammarström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Show others and affiliations
2009 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 4, no 11, e7806- p.Article in journal (Refereed) Published
Abstract [en]

We suggest that VCC is capable of causing an inflammatory response characterized by increased permeability and production of IL-8 and TNF-alpha in tight monolayers. Pure VCC at a concentration of 160 ng/ml caused an inflammatory response that reached the magnitude of that caused by Vibrio-secreted factors, while higher concentrations caused epithelial cell death. The inflammatory response was totally abolished by treatment with PrtV. The findings suggest that low doses of VCC initiate a local immune defense reaction while high doses lead to intestinal epithelial lesions. Furthermore, VCC is indeed a substrate for PrtV and PrtV seems to execute an environment-dependent modulation of the activity of VCC that may be the cause of V. cholerae reactogenicity.

Place, publisher, year, edition, pages
San Francisco: Public Library of Science , 2009. Vol. 4, no 11, e7806- p.
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-41945DOI: 10.1371/journal.pone.0007806OAI: oai:DiVA.org:umu-41945DiVA: diva2:408181
Available from: 2011-04-04 Created: 2011-04-04 Last updated: 2012-06-29Bibliographically approved

Open Access in DiVA

fulltext(900 kB)131 downloads
File information
File name FULLTEXT02.pdfFile size 900 kBChecksum SHA-512
71d5c4c0655040c0492546a527088acb0a3c0e34af85b945ff9256550c3b411cdbccbc6e6f4903b1c866661355f9d85192ece701e5d4b438e4d3c7c49ae3520c
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Ou, GangweiRompikuntal, Pramod KumarBitar, AzizLindmark, BarbroVaitkevicius, KarolisWai, Sun NyuntHammarström, Marie-Louise
By organisation
Immunology/ImmunchemistryDepartment of Molecular Biology (Faculty of Medicine)
In the same journal
PLoS ONE
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 131 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 147 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf