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Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry. (Hammarström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry. (Hammarström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2009 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 4, no 11, e7806- p.Article in journal (Refereed) Published
Abstract [en]

We suggest that VCC is capable of causing an inflammatory response characterized by increased permeability and production of IL-8 and TNF-alpha in tight monolayers. Pure VCC at a concentration of 160 ng/ml caused an inflammatory response that reached the magnitude of that caused by Vibrio-secreted factors, while higher concentrations caused epithelial cell death. The inflammatory response was totally abolished by treatment with PrtV. The findings suggest that low doses of VCC initiate a local immune defense reaction while high doses lead to intestinal epithelial lesions. Furthermore, VCC is indeed a substrate for PrtV and PrtV seems to execute an environment-dependent modulation of the activity of VCC that may be the cause of V. cholerae reactogenicity.

Place, publisher, year, edition, pages
San Francisco: Public Library of Science , 2009. Vol. 4, no 11, e7806- p.
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Immunology in the medical area
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URN: urn:nbn:se:umu:diva-41945DOI: 10.1371/journal.pone.0007806OAI: oai:DiVA.org:umu-41945DiVA: diva2:408181
Available from: 2011-04-04 Created: 2011-04-04 Last updated: 2012-06-29Bibliographically approved

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Ou, GangweiRompikuntal, Pramod KumarBitar, AzizLindmark, BarbroVaitkevicius, KarolisWai, Sun NyuntHammarström, Marie-Louise
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