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Bimatoprost effects on aqueous humor dynamics in monkeys
Linköping University, Faculty of Health Sciences.
Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
2010 (English)In: Journal of ophthalmology, ISSN 2090-0058, Vol. 2010, 926192- p.Article in journal (Refereed) Published
Abstract [en]

The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes. Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran. Total outflow facility was determined by the two-level constant pressure method. Aqueous flow was measured with a scanning ocular fluorophotometer. Uveoscleral outflow was 0.96 +/- 0.19 muL min(-1) in vehicle-treated eyes and 1.37 +/- 0.27 muL min(-1) (n = 6; P < .05) in eyes that received bimatoprost 0.01% b.i.d. x 5 days. Bimatoprost had no effect on total outflow facility, which was 0.42 +/- 0.05 muL min(-1) at baseline and 0.42 +/- 0.04 muL min(-1) after bimatoprost treatment. Bimatoprost had no significant effect on aqueous humor flow. This study demonstrates that bimatoprost increases uveoscleral outflow but not total outflow facility or aqueous humor flow, indicating that it lowers intraocular pressure in ocular normotensive monkeys by a mechanism that exclusively involves uveoscleral outflow.

Place, publisher, year, edition, pages
2010. Vol. 2010, 926192- p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-66505DOI: 10.1155/2010/926192PubMedID: 20508775OAI: oai:DiVA.org:liu-66505DiVA: diva2:404736
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2014-12-03

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