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Numerical simulation of failure response of vascular tissue due to deep penetration
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
2011 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology , 2011. , xiv p.
Series
Trita-HFL. Report / Royal Institute of Technology, Solid Mechanics, ISSN 1654-1472 ; 0500
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-30875OAI: oai:DiVA.org:kth-30875DiVA: diva2:402165
Presentation
2011-03-04, Sal E3, KTH, Osquars backe 14, Stockholm, 10:15
Opponent
Supervisors
Note

QC 20110307

Available from: 2011-03-07 Created: 2011-03-07 Last updated: 2013-01-15Bibliographically approved
List of papers
1. Numerical simulation of the failure of ventricular tissue due to deep penetration: The impact of constitutive properties
Open this publication in new window or tab >>Numerical simulation of the failure of ventricular tissue due to deep penetration: The impact of constitutive properties
2011 (English)In: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 44, no 1, 45-51 p.Article in journal (Refereed) Published
Abstract [en]

Lead perforation is a rare but serious clinical complication of pacemaker implantation, and towards understanding this malfunction, the present study investigated myocardial failure due to deep penetration by an advancing rigid punch. To this end, a non-linear Finite Element model was developed that integrates constitutive data published in the literature with information from in vitro tensile testing in cross-fibre direction of porcine myocardial tissue. The Finite Element model considered non-linear, isotropic and visco-elastic properties of the myocardium, and tissue failure was phenomenologically described by a Traction Separation Law. In vitro penetration testing of porcine myocardium was used to validate the Finite Element model, and a particular objective of the study was to investigate the impact of different constitutive parameters on the simulated results. Specifically, results demonstrated that visco-elastic properties of the tissue strongly determine the failure process, whereas dissipative effects directly related to failure had a minor impact on the simulation results. In addition, non-linearity of the bulk material did not change the predicted peak penetration force and the simulations did not reveal elastic crack-tip blunting. The performed study provided novel insights into ventricular failure due to deep penetration, and provided useful information with which to develop numerical failure models.

Keyword
Myocardium, Fracture, Penetration failure, Soft biological tissue, Pacemaker lead perforation, Constitutive properties, FEM, Cohesive zone, Fracture process zone, Visco-elastic, Non-linear
National Category
Other Engineering and Technologies not elsewhere specified
Identifiers
urn:nbn:se:kth:diva-30529 (URN)10.1016/j.jbiomech.2010.08.022 (DOI)000286550500008 ()2-s2.0-78650014072 (ScopusID)
Funder
Swedish Research Council, 2007-4514
Note
QC 20110304Available from: 2011-03-04 Created: 2011-02-28 Last updated: 2013-05-28Bibliographically approved
2. The numerical implementation of invariant-based viscoelastic formulations at finite strains. An anisotropic model for the passive myocardium
Open this publication in new window or tab >>The numerical implementation of invariant-based viscoelastic formulations at finite strains. An anisotropic model for the passive myocardium
2011 (English)In: Computer Methods in Applied Mechanics and Engineering, ISSN 0045-7825, E-ISSN 1879-2138, Vol. 200, no 49-52, 3637-3645 p.Article in journal (Refereed) Published
Abstract [en]

The present study developed a conceptual framework for finite strain viscoelasticity thought to be suitable to capture the salient features of a class of passive soft biological tissues like the myocardium. A superposition of a Maxwell Body and an Elastic Body defines the viscoelastic continuum, and its deformation is related to two independent reference configurations. The reference configuration of the Maxwell Body moves in space as it is described (apart from rigid body rotation) by a rate equation in strain space, and stores the history of the deformation. At thermodynamic equilibrium the reference configuration of the Maxwell Body coincides with the current configuration of the continuum. The Helmholtz free energy is expressed as a function of two independent strain variables and entirely renders the constitution of the viscoelastic body. Although this view is to some extent different from reported viscoelastic concepts for finite strains, its linearization around the thermodynamic equilibrium coincides with earlier suggested viscoelastic models. The linearized viscoelastic model has been implemented for a particular anisotropic constitutive model for the passive myocardium. Non-negative dissipation of the model is guaranteed. Material parameters were estimated from in vitro testing of porcine myocardium and the response due to pushing a rigid punch into the myocardium was studied. Results between anisotropic and isotropic descriptions of the myocardium differed significantly, which justified the implementation of an anisotropic model for the myocardium.

Keyword
finite strains, anisotropy, viscoelastic, myocardium, soft biological tissue, pacemaker lead perforation, constitutive properties, FEM, nonlinear
National Category
Engineering and Technology
Identifiers
urn:nbn:se:kth:diva-31037 (URN)10.1016/j.cma.2011.08.022 (DOI)000297494700011 ()2-s2.0-80053501618 (ScopusID)
Funder
Swedish Research Council, 2007-4514
Note
QC 20110307Available from: 2011-03-07 Created: 2011-03-07 Last updated: 2013-05-28Bibliographically approved

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