Improved calibration procedure for laser Doppler perfusion monitors
2011 (English)In: Optical Diagnostics and SensingXI: Toward Point-of-CareDiagnostics; and Design andPerformance Validation ofPhantoms Used in Conjunctionwith Optical Measurement ofTissue III / [ed] Robert J. Nordstrom; Gerard L. Coté, SPIE - International Society for Optical Engineering, 2011, 790602-1-790602-7 p.Conference paper (Other academic)
Commercial laser Doppler perfusion monitors are calibrated using the perfusion value, i.e. the first order moment of the Doppler power spectrum, from a measurement in a standardized microsphere colloidal suspension under Brownian motion. The calibration perfusion value depends on several parameters of the suspension that are difficult to keep constant with adequate accuracy, such as the concentration, temperature and the microsphere size distribution. The calibration procedure itself may therefore introduce significant errors in the measured values.
An altered calibration procedure, where the zero order moment is used is described and demonstrated in this paper. Since the above mentioned parameters only affect the frequency content of the Doppler power spectrum and not the total power, the zero order moment will be independent of those parameters. It is shown that the variation in the calibration value, as given by measurements on different scattering liquids with a wide range of scattering properties and temperatures, is only a few percent using the proposed method. For the conventional calibration procedure, this variation corresponds to an error introduced by merely a 1°C variation in the reference liquid temperature. The proposed calibration method also enables absolute level comparisons between measured and simulated Doppler power spectra.
Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2011. 790602-1-790602-7 p.
Proceedings of SPIE (Progress in biomedical optics and imaging), ISSN 1605-7422 ; Vol. 7906
Laser Doppler flowmetry, calibration, Brownian motion, optical phantoms
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:liu:diva-66091DOI: 10.1117/12.871938ISI: 000302694400002ISBN: 9780819484437OAI: oai:DiVA.org:liu-66091DiVA: diva2:401575
Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 22-26 January 2011, 22-24 January 2011, San Francisco, CA, USA
Original Publication: Ingemar Fredriksson, M. Larsson, T. Strömberg and F. Salomonsson, Improved calibration procedure for laser Doppler perfusion monitors, 2011. http://dx.doi.org/10.1117/12.871938 Copyright 2011 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
The publication is also included in the series Progress in Biomedical Optics and Imaging (ISSN 1605-7422) vol. 12 issue 24.2011-03-072011-03-032016-08-31Bibliographically approved