Change search
ReferencesLink to record
Permanent link

Direct link
Elevated levels of circulating matrix metalloproteinase-9 are associated with a dysregulated cortisol rhythm-A case-control study of coronary artery disease
County Hospital Ryhov.
Linköping University, Department of Medicine and Health Sciences, Division of Preventive and Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Public Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
2011 (English)In: PSYCHONEUROENDOCRINOLOGY, ISSN 0306-4530, Vol. 36, no 1, 139-143 p.Article in journal (Refereed) Published
Abstract [en]

A dysregulated cortisol pattern has been found to be associated with systemic inflammatory activity in patients with coronary artery disease (CAD). Matrix metalloproteinase (MMP)-9 is involved in both inflammation and matrix degradation and considered a main contributor to coronary plaque rupture. In this study, we hypothesized that a dysfunctional cortisol response also involved a failure to regulate systemic MMP-9 levels in CAD patients. Total MMP-9, active MMP-9 and the endogenous inhibitor TIMP-1 were measured in 30 CAD patients and 30 healthy controls. Morning and evening cortisol was measured in repeated saliva samples. Patients had higher levels of total and active MMP-9 (both p andlt; 0.01) and increased 24-h cortisol output (p andlt; 0.05) characterized by higher levels of evening cortisol (p = 0.011). MMP-9 was associated with evening cortisol (p andlt; 0.001) independent of smoking and inflammatory markers. Compared with controls, patients also showed a blunted cortisol response to stress. After stress, the levels of MMP-9 became significantly reduced in controls whereas they remained unchanged in patients. The data indicate that MMP-9 is differently regulated in patients due to a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis and emphasize the role of MMP-9 as a possible link between stress and cardiovascular disease.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2011. Vol. 36, no 1, 139-143 p.
Keyword [en]
Matrix metalloproteinase, Coronary artery disease, Cortisol, Stress
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-65932DOI: 10.1016/j.psyneuen.2010.06.012ISI: 000286299100015OAI: oai:DiVA.org:liu-65932DiVA: diva2:400800
Note
Original Publication: A Szymanowski, Margareta Kristenson and Lena Jonasson, Elevated levels of circulating matrix metalloproteinase-9 are associated with a dysregulated cortisol rhythm-A case-control study of coronary artery disease, 2011, PSYCHONEUROENDOCRINOLOGY, (36), 1, 139-143. http://dx.doi.org/10.1016/j.psyneuen.2010.06.012 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/ Available from: 2011-02-28 Created: 2011-02-28 Last updated: 2011-03-03

Open Access in DiVA

fulltext(314 kB)598 downloads
File information
File name FULLTEXT01.pdfFile size 314 kBChecksum SHA-512
4efc1bfa7798b0deee4d4651cae3af0010dc85faae5c50f76f16e43ed459ed0cd49f9ac92da5e83b97042fd6ed68b350553a66e4523b9c156023e382b1914bf9
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Kristenson, MargaretaJonasson, Lena
By organisation
Division of Preventive and Social Medicine and Public Health ScienceFaculty of Health SciencesCentre for Public Health SciencesCardiologyDepartment of Cardiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 598 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 91 hits
ReferencesLink to record
Permanent link

Direct link