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Energetics of cholesterol-modulated membrane permeabilities. A simulation study
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Molecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing effect on the permeation rate was observed, but under certainconditions results indicating an increased permeation rate with increasing cholesterolconcentration were also obtained.

 

Place, publisher, year, edition, pages
2011. , 34 p.
Series
UPTEC X, 11 003
Keyword [en]
Molecular dynamics, permeability, cholesterol, lipid bilayer, umbrella simulation, potential of mean force
Identifiers
URN: urn:nbn:se:uu:diva-147722OAI: oai:DiVA.org:uu-147722DiVA: diva2:400775
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Examiners
Available from: 2011-03-09 Created: 2011-02-28 Last updated: 2011-03-09Bibliographically approved

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fulltext(2867 kB)419 downloads
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Type fulltextMimetype application/pdf

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Wennberg, Christian
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