Change search
ReferencesLink to record
Permanent link

Direct link
Energetics of cholesterol-modulated membrane permeabilities. A simulation study
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Molecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing effect on the permeation rate was observed, but under certainconditions results indicating an increased permeation rate with increasing cholesterolconcentration were also obtained.


Place, publisher, year, edition, pages
2011. , 34 p.
UPTEC X, 11 003
Keyword [en]
Molecular dynamics, permeability, cholesterol, lipid bilayer, umbrella simulation, potential of mean force
URN: urn:nbn:se:uu:diva-147722OAI: diva2:400775
Physics, Chemistry, Mathematics
Available from: 2011-03-09 Created: 2011-02-28 Last updated: 2011-03-09Bibliographically approved

Open Access in DiVA

fulltext(2867 kB)420 downloads
File information
File name FULLTEXT01.pdfFile size 2867 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Wennberg, Christian
By organisation
Department of Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 420 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 772 hits
ReferencesLink to record
Permanent link

Direct link