Energetics of cholesterol-modulated membrane permeabilities. A simulation study
Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Molecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing effect on the permeation rate was observed, but under certainconditions results indicating an increased permeation rate with increasing cholesterolconcentration were also obtained.
Place, publisher, year, edition, pages
2011. , 34 p.
UPTEC X, 11 003
Molecular dynamics, permeability, cholesterol, lipid bilayer, umbrella simulation, potential of mean force
IdentifiersURN: urn:nbn:se:uu:diva-147722OAI: oai:DiVA.org:uu-147722DiVA: diva2:400775
UppsokPhysics, Chemistry, Mathematics
van der Spoel, David