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Persistent Chlamydia pneumonia serology is related to a more rapid decline in lung function in women but not in men
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2010 (English)In: BMC Pulmonary Medicine, ISSN 1471-2466, E-ISSN 1471-2466, Vol. 10, article id 44Article in journal (Refereed) Published
Abstract [en]

Background Chlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections. Aim: To estimate the long term respiratory effects of C pn with change in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) as a main outcome variable.

Methods The study comprised of 1109 subjects (500 men and 609 women, mean age 28 ± 6 years) that participated in the Reykjavik Heart Study of the Young. Spirometry and blood samples for measurements of IgG antibodies for C pn were done at inclusion and at the end of the follow-up period (mean follow-up time 27 ± 4 years).

Results Having IgG against C pn at both examinations was significantly associated to a larger decrease in FEV1 (6 mL/year) and FVC (7 mL/year) in women but not in men. In women the association between C pn and larger FEV1 decline was only found in women that smoked at baseline where having C pn IgG was associated with 10 mL/year decline compared to smokers without C pn IgG. These results were still significant after adjustment for age, smoking and change in body weight.

Conclusion Our results indicate that persistent C pn serology is related to increased decline in lung function in women but not in men. This effect was, however, primarily found in smoking women. This study is a further indication that the pathophysiological process leading to lung impairment may differ between men and women.

Place, publisher, year, edition, pages
2010. Vol. 10, article id 44
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Respiratory Medicine and Allergy
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URN: urn:nbn:se:uu:diva-140834DOI: 10.1186/1471-2466-10-44ISI: 000208592700044PubMedID: 20738859OAI: oai:DiVA.org:uu-140834DiVA, id: diva2:384500
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2017-12-11Bibliographically approved

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