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CORRELATION BETWEEN ENDOMETRIAL MARKERS AND PREGNANCYOUTCOME IN WOMEN WITH UNEXPLAINED INFERTILITY
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2010 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

ABSTRACT

A defect implantation process is the major reason for unexplained infertility. Estrogen andprogesterone are steroid hormones preparing the endometrium for implantation. They mediatetheir effect through their receptors: estrogen receptor alpha and beta and progesteronereceptor A and B, respectively. Leukemia inhibitory factor (LIF), which is also important forimplantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is downregulated by suppressors of cytokine signaling 1. The aim of the study was to compare thelevels of the steroid hormone receptors and LIF related factors in the endometrium of twogroups of women with the diagnosis unexplained infertility: one that became pregnant afterassisted reproduction and one that did not become pregnant. Before treatment of thesewomen, endometrial mRNA was collected during the window of implantation in themenstrual cycle. The levels of specific mRNAs were measured with real-time PCR. Womenwho had become pregnant had a significantly higher level of steroid hormone receptors. Thus,these proteins seem to be important for a pregnancy and may be suitable as receptivitymarkers.

Place, publisher, year, edition, pages
2010. , p. 11
Keywords [en]
Leukemia inhibitory factor (LIF), endometrial receptivity markers, blastocyst endometrial communication, real time PCR SYBR-green, window of implantation.
Identifiers
URN: urn:nbn:se:uu:diva-126380OAI: oai:DiVA.org:uu-126380DiVA, id: diva2:323490
Uppsok
Medicine
Supervisors
Examiners
Available from: 2010-06-14 Created: 2010-06-10 Last updated: 2010-06-14Bibliographically approved

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CiteExportLink to record
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