Microstimulation in The Brain: Does Microdialysis Influence the Activated Volume of Tissue?
2009 (English)In: Proceedings of the COMSOL Conference Milan 2009, Milan: COMSOL , 2009, , 7 p.Conference paper (Other academic)
Deep brain stimulation (DBS) has been established as an effective treatment for Parkinson’s disease and other movement disor- ders. The stimulation is currently administered using tetrode-macroelectrodes that target the subthalamic nucleus (STN). This often leads to side effects which bias the surrounding ar- eas, e.g. the speech centre. Targeting a spe- cific brain region can better be achieved with micro-stimulation electrodes with directed elec- trical field distribution. Experimental studies showed the effectiveness of microelectrode DBS by comparing neurotransmitter outflow before and after the stimulation. The neurotransmit- ter outflow in close proximity to the stimulation is hereby measured by means of microdialysis. To establish ideal distances and stimulation strength, the electric potential around the stim- ulation electrode and microdialysis membrane were modelled using comsol Multiphysics.
Place, publisher, year, edition, pages
Milan: COMSOL , 2009. , 7 p.
deep brain stimulation, electrode-brain interface, impedance, microdialysis, microelectrodes
IdentifiersURN: urn:nbn:se:miun:diva-10625OAI: oai:DiVA.org:miun-10625DiVA: diva2:280516
COMSOL Conference Milan 2009