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Is acetylcholine a signaling molecule for human colon cancer progression?
University of Gothenburg.
Karlstad University.
Kungälv District Hospital.
Växjö Central Hospital.
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2011 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 46, no 4, p. 446-455Article in journal (Refereed) Published
Abstract [en]

Objective. Non-neuronal acetylcholine (ACh) has been suggested to be a mediator for the development of various types of cancer. We analyzed a possible role for this molecule in carcinogenesis and/or progression of human colon cancer, in patient biopsies harvested from the colon during surgery. We addressed whether ACh synthesis (by choline acetyltransferase) and/or degradation (by ACh esterase), as well as the expression of the α7-subtype of the nicotinic ACh receptors, and the peptide ligand at the α7 receptors, secreted mammalian Ly6/urokinase-type plasminogen activator receptor-related protein-1, respectively, are deranged in tumor tissue as compared with macroscopically tumor-free colon tissue. Methods. A total of 38 patients were grouped for analysis based on their respective Dukes stage (either Dukes A + B or C + D). A mucosal tissue sample was harvested from macroscopically tumor-free colon tissue (i.e. control tissue), as well as from the tumor, and protein lysates were prepared for quantitative Western blotting. Full-thickness specimens were taken for immunohistochemistry. Results. For all the above named markers, there was a significant difference between control and tumor tissue with regard to protein levels, and there was, in addition, a significant difference in protein levels between the Dukes A + B and C + D groups. Conclusion. The current findings may suggest a role for ACh in colon carcinogenesis/cancer progression; the data obtained could have prognostic and/or therapeutic significance for this disease.

Place, publisher, year, edition, pages
2011. Vol. 46, no 4, p. 446-455
Keywords [en]
Acetylcholine, choline acetyltransferase, colon cancer, nicotinic acetylcholine receptor, SLURP-1
National Category
Cancer and Oncology
Research subject
Natural Science
Identifiers
URN: urn:nbn:se:hik:diva-2326DOI: 10.3109/00365521.2010.539252OAI: oai:DiVA.org:hik-2326DiVA, id: diva2:274919
Available from: 2009-11-03 Created: 2009-11-02 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
Open this publication in new window or tab >>Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer: Roles for the α7nAChR
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Kalmar: Högskolan i Kalmar, 2009. p. 60
Series
Dissertation series / University of Kalmar, Faculty of Natural Science, ISSN 1650-2779 ; 76
Keywords
alpha7 nicotinic acetylcholine receptor, acetylcholine, colorectal cancer, morphine, nicotine, plasminogen activator inhibitor-1, SLURP-1
National Category
Cancer and Oncology
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:hik:diva-2348 (URN)978-91-85993-37-6 (ISBN)
Public defence
2009-09-25, Falkens hörsal (C305), Nygatan 18B, Kalmar, 09:00 (English)
Opponent
Supervisors
Available from: 2009-11-04 Created: 2009-11-04 Last updated: 2016-03-11Bibliographically approved

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