We describe features of the X-ray: Generate and Analyse (XGA) open-source software package that have been developed tofacilitate automated hydrostatic mass (Mhydro ) measurements from XMM X-ray observations of clusters of galaxies. This includesdescribing how XGA measures global, and radial, X-ray properties of galaxy clusters. We then demonstrate the reliability ofXGA by comparing simple X-ray properties, namely the X-ray temperature and gas mass, with published values presented bythe XMM Cluster Survey (XCS), the Ultimate XMM eXtragaLactic survey project (XXL), and the Local Cluster SubstructureSurvey (LoCuSS). XGA measured values for temperature are, on average, within 1 per cent of the values reported in the literaturefor each sample. XGA gas masses for XXL clusters are shown to be ∼10 per cent lower than previous measurements (though thedifference is only significant at the ∼ 1.8σ level), LoCuSS R2500 and R500 gas mass re-measurements are 3 per cent and 7 per centlower, respectively (representing 1.5σ and 3.5σ differences). Like-for-like comparisons of hydrostatic mass are made to LoCuSSresults, which show that our measurements are 10±3 per cent (19±7 per cent) higher for R2500 (R500 ). The comparison betweenR500 masses shows significant scatter. Finally, we present new Mhydro measurements for 104 clusters from the Sloan DigitalSky Survey (SDSS) DR8 redMaPPer XCS sample (SDSSRM-XCS). Our SDSSRM-XCS hydrostatic mass measurements are ingood agreement with multiple literature estimates, and represent one of the largest samples of consistently measured hydrostaticmasses. We have demonstrated that XGA is a powerful tool for X-ray analysis of clusters; it will render complex-to-measureX-ray properties accessible to non-specialists.