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Predicting Shunt Surgery Outcomes in Idiopathic Normal pressure Hydrocephalus using Machine Learning
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre. (Caramba research group)
2025 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Idiopathic Normal Pressure Hydrocephalus (iNPH) is a neurodegenerative disorder that targets people of older age groups. It is a result of abnormal cerebrospinal fluid (CSF) buildup. To combat that, iNPH can be treated with a shunt surgery. However, predicting the success of the surgery remains a challenge due to the variability in patient outcomes. This study explores the use of machine learning (ML) to predict post-surgical outcomes in iNPH patients by utilizing clinical data from the Swedish Hydrocephalus Quality Registry (SHQR). Several ML models were tested, including random forest, decision trees, logistic regression, support vector machines (SVM), k-nearest neighbors (KNN), and gradient boosting, with random forest chosen as the final model due to its ability to handle of missing data. The results indicate that while ML models provide promising predictions, challenges such as higher rates of missing data, variations in measurement methods across years, and limitations in the availability of further descriptive features for the input set affect model accuracy. The final model achieved an accuracy of 66% and a macro F1-score of 64%, demonstrating the potential of ML in predicting iNPH surgical outcomes but highlighting the need for further refinement.

Place, publisher, year, edition, pages
2025. , p. 62
National Category
Medical Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:uu:diva-553868OAI: oai:DiVA.org:uu-553868DiVA, id: diva2:1949904
Educational program
Master Programme in Bioinformatics
Presentation
2025-02-27, Norbyvägen 16, Uppsala, 18:39 (English)
Supervisors
Examiners
Available from: 2025-04-04 Created: 2025-04-03 Last updated: 2025-04-04Bibliographically approved

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Biology Education Centre
Medical Bioinformatics and Systems Biology

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf