Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Results reporting for clinical trials led by medical universities and university hospitals in the nordic countries was often missing or delayed
Karolinska Inst, Dept Clin Neurosci, Tomtebodavagen 18A, S-17177 Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stockholm, Sweden.;Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..ORCID iD: 0000-0001-5273-0150
Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..
Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..ORCID iD: 0000-0003-1934-9504
Show others and affiliations
2025 (English)In: Journal of Clinical Epidemiology, ISSN 0895-4356, E-ISSN 1878-5921, Vol. 181, article id 111710Article in journal (Refereed) Published
Abstract [en]

Objectives: To systematically evaluate timely reporting of clinical trial results at medical universities and university hospitals in the Nordic countries.

Study Design and Setting: In this cross-sectional study, we included trials (regardless of intervention) registered in the European Union (EU) Clinical Trials Registry and/or ClinicalTrials.gov, completed 2016-2019 and led by a university with medical faculty or university hospital in Denmark, Finland, Iceland, Norway, or Sweden. We identified summary results posted at the trial registries and conducted systematic manual searches for results publications (eg, journal articles, preprints). We present proportions with 95% confidence intervals (CI) and medians with interquartile range (IQR). Protocol: https://osf.io/wua3r.

Results: Among 2112 included clinical trials, 1650 (78.1%, 95% CI 76.3%-79.8%) reported any results during our follow-up; 1097 (51.9%, 95% CI 49.8%-54.1%) reported any results within 2 years of the global completion date; and 48 (2.3%, 95% CI 1.7%-3.0%) posted summary results in the registry within 1 year. The median time from global completion date to results reporting was 690 days (IQR 1103). 856/1681 (50.9%) of ClinicalTrials.gov registrations were prospective. Denmark contributed approximately half of all trials. Reporting performance varied widely between institutions.

Conclusion: Missing and delayed results reporting of academically led clinical trials are a pervasive problem in the Nordic countries. We relied on trial registry information, which can be incomplete. Institutions, funders, and policymakers need to support trial teams, ensure regulation adherence, and secure trial reporting before results are permanently lost. (c) 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Place, publisher, year, edition, pages
Elsevier, 2025. Vol. 181, article id 111710
Keywords [en]
Trial registration, Publication bias, Metascience, Clinical trials, Evidence-based medicine, Missing results
National Category
Surgery Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:uu:diva-553531DOI: 10.1016/j.jclinepi.2025.111710ISI: 001444491800001PubMedID: 39900256Scopus ID: 2-s2.0-85219243130OAI: oai:DiVA.org:uu-553531DiVA, id: diva2:1948703
Funder
EU, Horizon 2020, 101094725EU, Horizon 2020, HORIZON-MS-CA-2022-DN-01 101120360Available from: 2025-03-31 Created: 2025-03-31 Last updated: 2025-03-31Bibliographically approved

Open Access in DiVA

fulltext(1423 kB)23 downloads
File information
File name FULLTEXT01.pdfFile size 1423 kBChecksum SHA-512
ef4d6a8e64569c249ed9a5e10bfd73de7b86e29ef21c8be4fb9dfcd8651d8dfffc1fe145a963918e499099b461cb2a3ee365fefc9eaf28f20feaa8353744217e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Nilsonne, GustavSalholz-Hillel, MaiaKlas, KatarzynaYerunkar, SamruddhiOlsson, NatashaBengtsson, JohanRingsten, MartinRaittio, EeroBruschettini, MatteoAxfors, Cathrine
By organisation
Department of Medical SciencesObstetrics and Reproductive Health Research
In the same journal
Journal of Clinical Epidemiology
SurgeryPublic Health, Global Health and Social Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 30 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 287 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf