Karolinska Inst, Dept Clin Neurosci, Tomtebodavagen 18A, S-17177 Stockholm, Sweden..
Karolinska Inst, Dept Clin Neurosci, Tomtebodavagen 18A, S-17177 Stockholm, Sweden.;UiT Arctic Univ Norway, Tromso, Norway.;TranspariMED, Stockholm, Sweden..
Univ Sarajevo, Fac Med, Sarajevo, Bosnia & Herceg..
Univ Guadalajara, Guadalajara, Mexico..
Jagiellonian Univ, Res Eth Med Study Grp REMEDY, Krakow, Poland..
UiT Arctic Univ Norway, Fac Hlth Sci, Dept Pharm, Tromso, Norway..
Jagiellonian Univ, Res Eth Med Study Grp REMEDY, Krakow, Poland..
Univ Westminster, Sch Life Sci, London, England..
Jagiellonian Univ, Res Eth Med Study Grp REMEDY, Krakow, Poland..
Univ Hosp Patras, Dept Internal Med, Patras, Greece..
Univ Oslo, Dept Psychol, Oslo, Norway..
Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden..
XLRI Jamshedpur, Jamshedpur, India..
Lund Univ, Dept Sociol, Lund, Sweden..
Univ Guadalajara, CUCS, Unit Ctr Hlth Sci, Guadalajara, Mexico..
Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA USA..
Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..
Acad Sci & Innovat Res, Ghaziabad, India.;Indian Inst Publ Hlth, Hyderabad, India..
Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland.;Univ Basel, Basel, Switzerland.;Univ Hosp Basel, Dept Clin Res, Basel, Switzerland..
Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA USA.;Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden..
Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..
Univ Basel, Basel, Switzerland.;Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland..
Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland.;Univ Basel, Basel, Switzerland.;Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland..
Univ Rennes, CHU Rennes, Inserm, Ctr Invest Clin Rennes CIC1414,Serv Pharmacol Clin, F-35000 Rennes, France.;Inst Univ France, Paris, France..
Karolinska Inst, Compliance & Data Off, Stockholm, Sweden..
Linnaeus Univ, Dept Criminol & Police Work, Växjö, Sweden.;Inst Globally Distributed Open Res & Educ IGDORE, Gothenburg, Sweden..
Acad Sci & Innovat Res, Ghaziabad, India.;Stanford Univ, Dept Med, Stanford, CA USA..
Charite Univ Med Berlin, Berlin Inst Hlth, QUEST Ctr Responsible Res, Berlin, Germany. Univ Oxford, Bennett Inst Appl Data Sci, Nuffield Dept Primary Care Hlth Sci, Oxford, Oxon, England..
Objectives: To systematically evaluate timely reporting of clinical trial results at medical universities and university hospitals in the Nordic countries.
Study Design and Setting: In this cross-sectional study, we included trials (regardless of intervention) registered in the European Union (EU) Clinical Trials Registry and/or ClinicalTrials.gov, completed 2016-2019 and led by a university with medical faculty or university hospital in Denmark, Finland, Iceland, Norway, or Sweden. We identified summary results posted at the trial registries and conducted systematic manual searches for results publications (eg, journal articles, preprints). We present proportions with 95% confidence intervals (CI) and medians with interquartile range (IQR). Protocol: https://osf.io/wua3r.
Results: Among 2112 included clinical trials, 1650 (78.1%, 95% CI 76.3%-79.8%) reported any results during our follow-up; 1097 (51.9%, 95% CI 49.8%-54.1%) reported any results within 2 years of the global completion date; and 48 (2.3%, 95% CI 1.7%-3.0%) posted summary results in the registry within 1 year. The median time from global completion date to results reporting was 690 days (IQR 1103). 856/1681 (50.9%) of ClinicalTrials.gov registrations were prospective. Denmark contributed approximately half of all trials. Reporting performance varied widely between institutions.
Conclusion: Missing and delayed results reporting of academically led clinical trials are a pervasive problem in the Nordic countries. We relied on trial registry information, which can be incomplete. Institutions, funders, and policymakers need to support trial teams, ensure regulation adherence, and secure trial reporting before results are permanently lost. (c) 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Elsevier, 2025. Vol. 181, article id 111710
Trial registration, Publication bias, Metascience, Clinical trials, Evidence-based medicine, Missing results