Objective: To describe the experiences of general-practising dental professionals in managing oral dryness. Materials and methods: The purposive selection of dentists and dental hygienists sought to create a cohort with varying years of professional experience, of both genders, and in dissimilar working regions and workplaces for one-on-one semi-structured interviews. Qualitative content analysis was used to identify themes and categories, where themes represented the interpretative aspect and categories, the descriptive aspect. Results: Thirteen informants were interviewed (4 dentists, 9 dental hygienists; of these, 9 worked in the Swedish Public Dental Service; 4, in private dental care). Two themes emerged from the analysis. The first theme, “Challenges in managing oral dryness”, comprised five categories: heterogeneity of the patient group, barriers to measuring salivary secretion, routines perceived as vague, lack of treatment options, and necessity to stay current. The second theme, “A patient-centred approach in managing oral dryness”, had three categories: tailoring questions to the individual, viewing the patient holistically, and sharing decision-making. Conclusion: Managing patients with oral dryness is challenging. The study suggests that a patient-centred approach, based on the individual needs of the patient, is crucial for managing patients with oral dryness in the dental situation. Clinical implications: This study stresses the importance of a patient-centred approach in providing individual support for patients with oral dryness. Dental professionals should query all patients about perceived dry mouth. In cases of positive responses, determination of the salivary secretion rate is essential for a comprehensive diagnosis.