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Outcomes after reconstructive surgery with local muscle flaps: Long- and short-term perspectives
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
2025 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Reconstructive surgery can be required as a result of complex wounds and tissue defects, which can occur after various types of injuries and surgical procedures. Tissue may need to be transferred to the affected area to restore form and function as much as possible, which can be done in several ways. Local muscle flaps have been used frequently for the reconstruction of various wounds and tissue defects historically, but questions remain regarding the outcomes after the use of specific muscle flaps in the short- as well as the long-term perspective. In this thesis different outcome perspectives are studied in patient groups who had reconstructive surgery with local muscle or musculocutaneous flaps in Linköping University Hospital due to complex wounds or tissue defects.

In paper I, the outcomes after sternal reconstruction using a unilateral pectoralis major advancement flap following deep sternal wound infection (DSWI) were evaluated. The results of the study show that the sternal reconstruction was successful in most cases and contributed to healing of the infection. Surgical complications were however relatively common, and some patients required reoperations due to complications.

Paper II investigated the outcomes after reconstruction of deep pressure ulcers in the pelvic area using local musculocutaneous and fasciocutaneous flaps, in a patient cohort in which the majority had spinal cord injury (SCI). Flap viability was compared between different types of flaps and techniques. The results of the study conclude that musculocutaneous and fasciocutaneous flaps have similar viability and that a certain type of flap was associated with an increased risk of flap failure.

In paper III, long-term outcomes after breast reconstruction following breast cancer using the extended latissimus dorsi myocutaneous flap were evaluated, using the patient-reported outcome measure (PROM) BREAST-Q. The results of the study show a high level of long-term patient satisfaction following this method of breast reconstruction, which seems to increase over time.

Paper IV investigated long-term outcomes following reconstruction of complex wounds around the foot and ankle using the extensor digitorum brevis (EDB) muscle flap. Outcomes were assessed using both PROMs and functional measurements. Overall, the results of the study show that foot and ankle function does not appear to be significantly affected by the harvest of the EDB muscle flap.

In summary, patients who have had reconstructive surgery with muscle flaps constitute a complex heterogeneous group. The studies in this thesis add knowledge regarding short- and long-term outcomes after reconstructive surgery using specific muscle flaps, which can be valuable when considering the appropriate surgical method for the individual patient.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2025. , p. 68
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1953
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-211515DOI: 10.3384/9789180758918ISBN: 9789180758901 (print)ISBN: 9789180758918 (electronic)OAI: oai:DiVA.org:liu-211515DiVA, id: diva2:1935347
Public defence
2025-03-21, Belladonna, Building 511, Campus US, 13:00 (English)
Opponent
Supervisors
Available from: 2025-02-06 Created: 2025-02-06 Last updated: 2025-02-14Bibliographically approved
List of papers
1. Reconstruction of sternal defects after sternotomy with postoperative osteomyelitis, using a unilateral pectoralis major advancement muscle flap
Open this publication in new window or tab >>Reconstruction of sternal defects after sternotomy with postoperative osteomyelitis, using a unilateral pectoralis major advancement muscle flap
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2020 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 10, no 1, article id 8380Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The pectoralis major flap, which is usually harvested bilaterally, is considered a workhorse flap in the reconstruction of sternal defects. After a median sternotomy for open heart surgery, 1%-3% of patients develop deep infection and dehiscence of the sternal wound, some of which will eventually require reconstructive surgery. Our aim was to describe the clinical feasibility and associated complications of the unilateral pectoralis major advancement flap in the reconstruction of sternal defects.

METHODS: A retrospective analysis of all adult patients who were operated on using a unilateral pectoralis major flap for reconstruction of the chest wall at the Linköping University Hospital during 2008-18 was made using data retrieved from medical records.

RESULTS: Forty-three patients had reconstructions with unilateral pectoralis major flaps. Three flaps failed completely, and another 10 patients developed complications that required further operation. The factors that were independently associated with loss of the flaps and complications were: older age, male sex, the number of different antibiotics used, and a long duration of treatment with negative wound pressure. Fewer wound revisions before the reconstruction resulted in more complications. The factors that were independently associated with prolonged time to complete healing were emergency reoperation after the initial operation and complications after reconstruction.

CONCLUSION: The unilateral pectoralis major advancement flap has proved to be a useful technique in the reconstruction of most sternal defects after sternal wound infection in older patients. There is, however, need for a follow-up study on a larger number of procedures to evaluate the long-term outcome compared with other methods of sternal reconstruction.

Place, publisher, year, edition, pages
Nature Publishing Group, 2020
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-165783 (URN)10.1038/s41598-020-65398-y (DOI)000540464700002 ()32433505 (PubMedID)2-s2.0-85085157668 (Scopus ID)
Note

Funding agencies: Linkoping University

Available from: 2020-05-25 Created: 2020-05-25 Last updated: 2025-02-06Bibliographically approved
2. Flap Survival after Reconstructive Surgery for Pressure Ulcers: A Cohort Study
Open this publication in new window or tab >>Flap Survival after Reconstructive Surgery for Pressure Ulcers: A Cohort Study
2023 (English)In: Plastic and Reconstructive Surgery - Global Open, E-ISSN 2169-7574, Vol. 11, no 12, p. e5451-e5451Article in journal (Refereed) Published
Abstract [en]

Background: Pressure ulcers are troublesome for patients and require considerable resources to resolve. Previous studies have focused on recurrence, whereas there are few studies on flap survival. The aim was to describe the group and to analyze possible factors for flap survival.

Method: A descriptive retrospective analysis of all operations between 2008 and 2020 was carried out. Flap survival at 40 days was assessed. A flap was classified as a failure if a reoperation with removal or replacement was planned before, or in connection with, the first return visit. Variables of patient demographics, details of the pressure ulcers, and surgical treatment and care were analyzed with multivariable logistic regression for their effect on flap survival.

Results: A total of 111 flaps were included [78 (70%) with random blood supply and 33 (30%) with axial or perforator-based blood supply]; 54 (49%) of the flaps were fasciocutaneous. Body mass index was 25 (IQR 22–28). Flap survival rate was 90%. Variables associated with flap failure were higher body mass index, congenital spinal cord injury, type of blood supply to the flap, and the use of methylene blue to guide debridement of the wound.

Conclusions: The findings show factors that can be modified to improve future results, including a normalized body mass index and use of methylene blue in surgery to outline wound edges and depth, as this has been shown to protect against flap failure. Our data suggest that random flaps, such as V-Y, are preferable to axial flaps in the studied group.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2023
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-199650 (URN)10.1097/gox.0000000000005451 (DOI)001125354000008 ()38098948 (PubMedID)
Available from: 2023-12-15 Created: 2023-12-15 Last updated: 2025-02-06Bibliographically approved
3. Breast Reconstruction Using the Extended Latissimus Dorsi Myocutaneous Flap—A Long-term Follow-up Utilizing BREAST-Q
Open this publication in new window or tab >>Breast Reconstruction Using the Extended Latissimus Dorsi Myocutaneous Flap—A Long-term Follow-up Utilizing BREAST-Q
2024 (English)In: Aesthetic Surgery Journal Open Forum, E-ISSN 2631-4797, Vol. 6, article id ojae002Article in journal (Refereed) Published
Abstract [en]

Background The latissimus dorsi (LD) flap is a commonly used method for breast reconstruction after mastectomy. In this study, we present a long-term follow-up and effects of refining surgery on patient satisfaction and quality of life after breast reconstruction with the extended LD flap, using the BREAST-Q questionnaire.

Objectives The aim of this study was to investigate the patient-reported long-term results after breast reconstruction with the extended LD myocutaneous flap.

Methods A retrospective cohort study of adult patients (n = 101) who were operated on using the extended LD flap for breast reconstruction at the Linköping University Hospital during 1997 to 2012 was made using data retrieved from medical records. The patients were asked to complete the BREAST-Q questionnaire at 2 different postoperative time points.

Results Eighty-three patients replied to the first questionnaire, and 56 patients also replied to the second. Mean follow-up was 11.7 years. Higher age and living together with someone correlated to higher BREAST-Q results, while postoperative infection, bilateral LD flaps, smoking, and prior breast surgery had a negative impact on the results. Overall BREAST-Q results increased over time. No independent effect of refining surgery could be shown.

Conclusions Patient satisfaction after breast reconstruction with the LD flap as measured with the BREAST-Q questionnaire is high and in line with other studies. The overall satisfaction with the reconstruction method seems to increase with time, but no further increase in satisfaction after refining surgery could be established. Level of Evidence: 3 

Place, publisher, year, edition, pages
Oxford University Press, 2024
Keywords
follow-up; mammaplasty; surgical procedures; operative; breast
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-200856 (URN)10.1093/asjof/ojae002 (DOI)001157814200001 ()
Note

Funding: Department of Hand Surgery, Plastic Surgery and Burns, Linkoping University Hospital, Region Ostergotland, and the Linkoeping University, Linkoeping, Sweden

Available from: 2024-02-12 Created: 2024-02-12 Last updated: 2025-03-18Bibliographically approved

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