The aim of this study is to explore the perceptions that treatment providers have regarding polydrug use and what these perceptions are based on, as well as to examine the consequences these perceptions may have for polydrug users. Through a qualitative research method and interviews with six treatment providers, data has been analyzed using Goffman’s (1963/2011) theory of stigmatization. Findings show that treatment providers have a perception of polydrug use being used as a form of strategy to self-medicate and cope with difficult life situations and stigmatization. Other results suggest that treatment providers show understanding of polydrug use and consider factors that influence it, which can reduce blame and negative stereotypes, thereby reducing stigma for polydrug users. The findings reveal two main perspectives in treatment providers' perception of polydrug use: a medical and a social view, influencing providers' views. Furthermore, treatment providers emphasize that clients with polydrug use have not received the appropriate help and support, resulting in an ambition amongst treatment providers to build clients’ trust and motivate seeking help. Additionally, the results also indicate that treatment providers believe other treatment providers’ own experience with substance abuse can positively impact the treatment of polydrug use.