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Dietary L-Tryptophan Suppresses Aggression and Stress Responsiveness in Juvenile Rainbow Trout (Oncorhynchus mykiss): The Role of Brain Serotonin and Plasma Melatonin
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Comparative Physiology.
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Juvenile rainbow trout (Oncorhynchus mykiss) fed L-tryptophan (TRP) supplemented feed for 7 days show a suppression of aggressive behaviour along with a reduction in post-stress plasma cortisol levels. However, 3 days of elevated dietary TRP does not have any effects on either aggressive behaviour or post-stress plasma cortisol levels. The effects of TRP on aggression and stress responsiveness could be related to elevated brain serotonergic activity, TRP being the precursor of serotonin (5-HT). However, 5-HT is, in turn, the precursor of melatonin (ME) and we found that elevated dietary intake of TRP results in an increase in daytime plasma levels of ME. Elevated plasma ME concentrations in rainbow trout fed TRP supplemented feed appear to be of gastrointestinal origin. ME has been suggested to have inhibitory effects on aggressive behaviour and to act as a glucocorticoid antisecretagogue. However, we found that exogenuos ME did not affect aggressive behaviour or post-stress plasma cortisol in rainbow trout. Instead, the effects of TRP on aggressive behaviour and plasma cortisol were mimicked by treatment with the selective serotonin re-uptake inhibitor, citalopram, suggesting that the effects of TRP are mediated by a stimulation of brain 5-HT activity and not by increased ME synthesis and secretion. However, the slow time-course of the effects of TRP on aggressive behaviour and plasma cortisol suggests that effects on 5-HT receptors mechanism are likely to be involved.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2004. , p. 55
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 1014
Keywords [en]
Biology, serotonin, brain, fish, rainbow trout, Oncorhynchus mykiss, feed, stress, cortisol, melatonin, behaviour, aggression
Keywords [sv]
Biologi
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-4555ISBN: 91-554-6040-2 (print)OAI: oai:DiVA.org:uu-4555DiVA, id: diva2:165113
Public defence
2004-10-09, Lindahlsalen 01.01058, Evolutionary biology centre, Norbyvägen 18A, S-752 32, Uppsala, 10:00 (English)
Opponent
Supervisors
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2009-04-03Bibliographically approved
List of papers
1. Suppression of aggression in rainbow trout (Oncorhynchus mykiss) by dietary L-tryptophan
Open this publication in new window or tab >>Suppression of aggression in rainbow trout (Oncorhynchus mykiss) by dietary L-tryptophan
2001 (English)In: The journal of experimental biology, ISSN 0022-0949, Vol. 204, no 22, p. 3867-3876Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-92137 (URN)
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2009-04-03Bibliographically approved
2. Elevated dietary intake of L-tryptophan counteracts the stress-induced elevation of plasma cortisol in rainbow trout (Oncorhynchus mykiss)
Open this publication in new window or tab >>Elevated dietary intake of L-tryptophan counteracts the stress-induced elevation of plasma cortisol in rainbow trout (Oncorhynchus mykiss)
2002 (English)In: The journal of experimental biology, ISSN 0022-0949, Vol. 205, no 23, p. 3679-3687Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-92138 (URN)
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2009-04-03Bibliographically approved
3. Time course of the effect of dietary L-tryptophan on plasma cortisol levels in rainbow trout Onchorhynchus mykiss
Open this publication in new window or tab >>Time course of the effect of dietary L-tryptophan on plasma cortisol levels in rainbow trout Onchorhynchus mykiss
2003 (English)In: The journal of experimental biology, ISSN 0022-0949, Vol. 206, no 20, p. 3589-3599Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-92139 (URN)
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2009-04-03Bibliographically approved
4. Tryptophan affects both gastrointestinal melatonin production and interrenal activity in stressed and non-stressed rainbow trout
Open this publication in new window or tab >>Tryptophan affects both gastrointestinal melatonin production and interrenal activity in stressed and non-stressed rainbow trout
(English)Manuscript (Other (popular science, discussion, etc.))
Identifiers
urn:nbn:se:uu:diva-92140 (URN)
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2010-01-14Bibliographically approved
5. Serotonin but not melatonin, plays a role in shaping dominant-subordinate relationships and aggression in rainbow trout
Open this publication in new window or tab >>Serotonin but not melatonin, plays a role in shaping dominant-subordinate relationships and aggression in rainbow trout
(English)Manuscript (Other (popular science, discussion, etc.))
Identifiers
urn:nbn:se:uu:diva-92141 (URN)
Available from: 2004-09-17 Created: 2004-09-17 Last updated: 2010-01-14Bibliographically approved

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