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Mitochondrial Evolution: Turning Bugs into Features
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The bacterial origin of mitochondria from an ancient endosymbiosis is now widely accepted and the mitochondrial ancestor is generally believed to belong to the bacterial subdivision α-proteobacteria. The high fraction of mitochondrial proteins encoded in the nucleus has commonly been explained with a massive transfer of genes from the genome of the ancestral mitochondrion.

The aim of this work was to get a better understanding of the mitochondrial origin and evolution by comparative genomics and phylogenetic analyses on mitochondria and α-proteobacteria. To this end, we sequenced the genomes of the intracellular parasites Bartonella henselae and Bartonella quintana, the causative agents of cat-scratch disease and trench fever, and compared them with other α-proteobacteria as well as mitochondrial eukaryotes.

Our results suggest that the adaptation to an intracellular life-style is coupled to an increased rate of genome degradation and a reduced ability to accommodate environmental changes. Reconstruction of the α-proteobacterial ancestor and phylogenetic analyses of the mitochondrial proteome in yeast revealed that only a small fraction of the proteins used for mitochondrial functions could be traced to the α-proteobacteria. Furthermore, a substantial fraction of the mitochondrial proteins was of eukaryotic origin and while most of the genes of the α-proteobacterial ancestor have been lost, many of those that have been transferred to the nuclear genome seem to encode non-mitochondrial proteins.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2004. , p. 37
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 961
Keywords [en]
Biology
Keywords [sv]
Biologi
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-4216ISBN: 91-554-5933-1 (print)OAI: oai:DiVA.org:uu-4216DiVA, id: diva2:164393
Public defence
2004-05-14, Ekmansalen, Kärnhuset, EBC, Uppsala, 13:15
Opponent
Supervisors
Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved
List of papers
1. The dual origin of the yeast mitochondrial proteome
Open this publication in new window or tab >>The dual origin of the yeast mitochondrial proteome
2000 In: Yeast, Vol. 17, p. 170-187Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91598 (URN)
Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved
2. Deep origin of plastid/parasite ATP/ADP translocases
Open this publication in new window or tab >>Deep origin of plastid/parasite ATP/ADP translocases
2003 In: J Mol Evol, Vol. 56, p. 137-150Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91599 (URN)
Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved
3. The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae
Open this publication in new window or tab >>The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae
Show others...
2004 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 101, no 26, p. 9716-9721Article in journal (Refereed) Published
Abstract [en]

We present the complete genomes of two human pathogens, Bartonella quintana (1,581,384 bp) and Bartonella henselae (1,931,047 bp). The two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. A primary difference between the two pathogens is their reservoir ecology. Whereas B. quintana is a specialist, using only the human as a reservoir, B. henselae is more promiscuous and is frequently isolated from both cats and humans. Genome comparison elucidated a high degree of overall similarity with major differences being B. henselae specific genomic islands coding for filamentous hemagglutinin, and evidence of extensive genome reduction in B. quintana, reminiscent of that found in Rickettsia prowazekii. Both genomes are reduced versions of chromosome I from the highly related pathogen Brucella melitensis. Flanked by two rRNA operons is a segment with similarity to genes located on chromosome II of B. melitensis, suggesting that it was acquired by integration of megareplicon DNA in a common ancestor of the two Bartonella species. Comparisons of the vector-host ecology of these organisms suggest that the utilization of host-restricted vectors is associated with accelerated rates of genome degradation and may explain why human pathogens transmitted by specialist vectors are outnumbered by zoonotic agents, which use vectors of broad host ranges.

National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-91600 (URN)10.1073/pnas.0305659101 (DOI)
Available from: 2004-04-13 Created: 2004-04-13 Last updated: 2017-12-14Bibliographically approved
4. Inferring the α-proteobacterial ancestor
Open this publication in new window or tab >>Inferring the α-proteobacterial ancestor
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In: Proc Natl Acad Sci USAArticle in journal (Refereed) Submitted
Identifiers
urn:nbn:se:uu:diva-91601 (URN)
Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved

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