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Aspects of Social Phobia
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Social phobia is a disabling, lifelong disorder characterised by fear in social settings.

The aim of the present study was to gain more knowledge about diagnostic, neurobiologic and epidemiologic aspects of social phobia.

Thirty-two individuals were assessed by the Structured Clinical Interview for DSM-IV Axis I and II psychiatric disorders, the Karolinska Scales of Personality and the Temperament and Character Inventory. Social phobia was accompanied by concurrent axis I disorders in about 28% of individuals, lifetime axis I disorders in 54%, personality disorders in 60%, and avoidant personality disorder (APD) in 47%. This suggests that there is a high comorbidity between social phobia and APD according to the DSM-IV criteria. The personality profiles associated with social phobia were dominated by anxiety-related traits that were primarily related to social phobia itself and not to the presence of concurrent personality disorders.

Eighteen subjects with social phobia and eighteen controls were investigated with positron emission tomography and the radiolabeled serotonin precursor, [3 -11C]–5-HTP (5-HTP). Individuals with social phobia demonstrated proportionally lower regional relative whole brain accumulation of 5-HTP in areas of the frontal and temporal cortices as well as the striatum, but higher accumulation in the cerebellum. This suggests that there are imbalances in presynaptic serotonin function in individuals with social phobia, although this could only be confirmed in men, and not in women.

By means of a postal survey, distributed to 2000 randomly selected individuals, social phobia in Sweden was found to be common, with a point prevalence of 15.6%.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2003. , p. 71
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1230
Keywords [en]
Neurosciences, Social phobia, personality disorders, personality traits, prevalence, serotonin, PET, [3 -11C]–5-HTP
Keywords [sv]
Neurovetenskap
National Category
Neurology
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-3323ISBN: 91-554-5551-4 (print)OAI: oai:DiVA.org:uu-3323DiVA, id: diva2:162392
Public defence
2003-05-26, Gustavianum, Uppsala, 13:15
Opponent
Available from: 2003-04-30 Created: 2003-04-30Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
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  • Other style
More styles
Language
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  • nn-NB
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  • Other locale
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Output format
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