Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Left Ventricular Function in Elderly Men: Metabolic, Hormonal, Genetic and Prognostic Implications
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Heart failure and left ventricular dysfunction are major causes of morbidity and mortality. In this thesis, metabolic, hormonal, genetic and prognostic aspects of echocardiographically determined left ventricular function were investigated in a fairly large longitudinal population-based study of men. The participants were examined both at age 50 and 70 years and were followed for mortality using the national cause-of-death registry.

Several factors associated with the insulin resistance syndrome predicted left ventricular systolic dysfunction independent of myocardial infarction, hypertension, diabetes and the use of cardiovascular medication after twenty years follow-up. Plasma levels of N-terminal atrial natriuretic peptide (N-ANP) were significantly increased in men with left ventricular dysfunction in comparison to healthy men. However, the diagnostic accuracy was poor due to the extensive overlapping between the groups. Relations between a haplotype of the novel hUNC-93B1 gene and the E/A-ratio were found and validated in separate samples of the cohort. Myocardial performance index (a Doppler derived index of combined left ventricular systolic and diastolic function) and left ventricular ejection fraction were found to be predictors for cardiovascular mortality independent of traditional cardiovascular risk factors in a longitudinal analysis with a mean follow-up of seven years.

In conclusion, this thesis showed that left ventricular function is influenced by metabolic, hormonal and genetic factors and that echocardiographic measurements of left ventricular function, such as the myocardial performance index, are strong independent risk factors for cardiovascular mortality in elderly men.

Place, publisher, year, edition, pages
Uppsala: Tryck och medier , 2002. , p. 57
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1204
Keywords [en]
Medicine, echocardiography, heart failure, left ventricular function, genetics, mortality, insulin sensitivity, natriuretic peptides
Keywords [sv]
Medicin
National Category
Dermatology and Venereal Diseases
Research subject
Geriatrics
Identifiers
URN: urn:nbn:se:uu:diva-2937ISBN: 91-554-5458-5 (print)OAI: oai:DiVA.org:uu-2937DiVA, id: diva2:162163
Public defence
2002-12-07, Sal X, Universitetshuset, Uppsala, 09:15
Opponent
Available from: 2002-11-14 Created: 2002-11-14Bibliographically approved

Open Access in DiVA

fulltext(382 kB)1358 downloads
File information
File name FULLTEXT01.pdfFile size 382 kBChecksum MD5
d664b99ba1dac17f05574dd8f6a86829fc4f574e4b36cb3cfc3b7b297e214b0ab26c6921
Type fulltextMimetype application/pdf
Buy this publication >>

By organisation
Department of Public Health and Caring Sciences
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar
Total: 1358 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 1252 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf