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α1- and α2-Adrenoceptors in the Eye: Pharmacological and Functional Characterization
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
2001 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

α1- and α2-Adrenoceptors are involved in various physiological events in the eye: blood flow regulation, aqueous humor dynamics and pupil regulation. The α1- and α2-adrenoceptors can be further subdivided into six subtypes (α1A, α1B, α1D, α2A , α2B, and α2C ). Currently available α1- and α2-adrenergic drugs are not selective for the different subtypes and some ocular adrenergics have undesirable side-effects, both local and systemic. A better understanding of the subtype distribution in the eye would be useful when designing new drugs with greater efficacy and fewer adverse effects; this applies especially to the treatment of glaucoma. The purpose of the thesis was therefore to identify and localize the different subtypes of α1- and α2-adrenoceptors in the eye.

The identities of the α1-adrenoceptor subtypes were studied in various parts of pig and albino rabbit eyes by radioligand binding. In the pig retina and in the albino rabbit iris, ciliary body and retina, mixed populations of α1A- and α1B-adrenoceptors were localized. In the rabbit choroid only the α1A-adrenoceptor subtype was detected.

The α2-adrenoceptor subtypes were also characterized by radioligand binding, in different parts of the pig eye. In the iris, ciliary body and choroid, only α2A-adrenoceptors were localized, while in the retina, mostly α2A-adrenoceptors and a minor population of α2C-adrenoceptors were identified. High densities of α2A-adrenoceptors were found in the ciliary body and choroid.

The effect of α2-adrenoceptor agonists on the porcine ciliary artery was studied on a small-vessel myograph. α2-Adrenoceptor agonists proved to be potent vasoconstrictors in the porcine ciliary artery and it was found that the vasoconstriction induced by brimonidine was mediated by the αA-adrenoceptor.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2001. , p. 66
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1058
Keywords [en]
Neurosciences, α1-adrenoceptor subtypes, α2-adrenoceptor subtypes, iris, ciliary body, choroid, retina, ciliary artery
Keywords [sv]
Neurovetenskap
National Category
Neurology
Research subject
Ophtalmology
Identifiers
URN: urn:nbn:se:uu:diva-1383ISBN: 91-554-5077-6 (print)OAI: oai:DiVA.org:uu-1383DiVA, id: diva2:160872
Public defence
2001-09-25, Rudbecksalen, Rudbeckslaboratoriet, Dag Hammarskjöld väg 20, Uppsala, Uppsala, 09:15
Opponent
Available from: 2001-09-25 Created: 2001-09-25Bibliographically approved

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