Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Asthma and all-cause mortality in children and young adults - a Swedish population based study
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-6851-3297
Show others and affiliations
2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, no Suppl. 63Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Little is known about the relationship between asthma in children and young adults and all-cause mortality. Studies suggest an increased rate of death among adults with asthma. Additionally among children, there is a rising prevalence of life-limiting conditions, defined as conditions with no hope of cure.

Aim: To investigate the association between asthma and all-cause mortality in children and young adults aged 1-25 years and to explore if this effect is modified by life-limiting conditions.

Method: This register based study includes 2,775,430 individuals born in Sweden between January 1986 and December 2012. Asthma cases, those with life-limiting conditions and other covariates were identified using Swedish national registers. The association between asthma and all-cause mortality was estimated using Cox proportional hazards model. A Cox model with an interaction term between asthma and life-limiting condition was also fitted to assess effect modification.

Results: 261,322 asthma cases were identified during the follow-up. The unadjusted all-cause mortality rate for asthma cases was greater than for non-asthma cases with a hazard ratio (HR) of 1.67 (95% CI 1.54-1.83). Adjusting for covariates altered the HR to 1.46 (95% CI 1.33-1.62). Having a life-limiting condition was a significant effect modifier (p=0.002); for patients with a life-limiting condition the HR was 1.86 (95% CI 1.57-2.22) and in patients without a life-limiting condition the HR was 1.33 (95% CI 1.18-1.49).

Conclusion: All-cause mortality in children and young adults is higher in those with asthma compared to those without asthma. Life-limiting conditions modify the effect of asthma on all-cause mortality.

Place, publisher, year, edition, pages
European Respiratory Society , 2019. Vol. 54, no Suppl. 63
Keywords [en]
Comorbidities
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:oru:diva-79828DOI: 10.1183/13993003.congress-2019.OA4972ISI: 000507372400404OAI: oai:DiVA.org:oru-79828DiVA, id: diva2:1392125
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, Spain, September 28 - October 2, 2019
Available from: 2020-02-06 Created: 2020-02-06 Last updated: 2020-02-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Search in DiVA

By author/editor
Larsson, Henrik
By organisation
School of Medical Sciences
In the same journal
European Respiratory Journal
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 5 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf